Fenofibrate Impurity 18 CAS CATO-C4X-101818
| CAS No. | CATO-C4X-101818 |
| Molecular Formula | C20H19ClO4 |
| Molecular Weight | 358.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fenofibrate Impurity 18.
CATO supplies Fenofibrate Impurity 18 (CAS CATO-C4X-101818), a pharmacopoeial impurity reference standard (molecular formula C20H19ClO4, MW 358.82 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Fenofibrate Impurity 18 (C20H19ClO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fenofibrate Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H19ClO4 |
| Molecular Weight | 358.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Fenofibrate Standards
- Fenofibrate Impurity 17 (CAS CATO-C4X-101817)
- Fenofibrate Impurity 10 (CAS CATO-C4X-164310)
- Fenofibrate (CAS 49562-28-9)
- Fenofibrate Dihydro Impurity (CAS 61001-99-8)
- Fenofibrate Impurity 33 (CAS 62809-68-1)
- Fenofibrate EP Impurity E (CAS 42019-07-8)
- Fenofibrate Impurity 9 (CAS CATO-C4X-16439)
- Fenofibrate Impurity 16 (CAS CATO-C4X-101816)
Recommended Standards
- (E)-N'-{7-[1-(4-chloro-2-methylphenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N,N-dimethylmethanimidamide (CAS 477865-38-6)
- Ethyl 2-{[6-chloro-2-(4-methylphenyl)-1H-1,3-benzimidazol-1-yl]oxy}propanoate (CAS 282523-55-1)
- 5-(Chloromethyl)-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-methanesulfonyl-1h-imidazole (CAS 1221342-91-1)
- 6-(3-Aminopropoxy)-N-(3-chlorophenyl)-7-methoxyquinazolin-4-amine (CAS 655247-74-8)
- Opicapone Impurity 41 (CAS CATO-C4X-240441)
- Serotonin Impurity 10 (CAS CATO-C4X-253410)
- Ebastine Impurity 20 (CAS CATO-C4X-202920)
- 2-{[(2-methylphenyl)(phenyl)methoxy]methyl}oxirane (CAS 19574-83-5)
- 5-(5-Bromo-2-fluorophenyl)-1,3,4-thiadiazol-2-amine (CAS 299441-49-9)
- tert-Butyl (3-methyl-4H-1,2,4-triazol-4-yl)carbamate (CAS 209797-71-7)
- 1-Methylpyrrolidinone-5,5,-d2 (CAS 128991-09-3)
- 2-((2,6-Dinitro-4-(trifluoromethyl)phenyl)amino)-N,3,3-trimethylbutanamide (CAS 477768-37-9)
- Carprofen glucuronide (CAS 76319-13-6)
- Tirzepatide Impurity 23 X TFA Salt (CAS CATO-C4X-324023)
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