Fluconazole EP Impurity F (R-Isomer) CAS CATO-C4X-101964
| CAS No. | CATO-C4X-101964 |
| Molecular Formula | C11H11F2N3O2 |
| Molecular Weight | 255.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Fluconazole EP Impurity F (R-Isomer) (CAS CATO-C4X-101964) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11F2N3O2 and a molecular weight of 255.22 g/mol.
Fluconazole EP Impurity F (R-Isomer) (C11H11F2N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11F2N3O2 |
| Molecular Weight | 255.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluconazole Standards
- Fluconazole EP Impurity F (CAS 118689-07-9)
- Fluconazole Impurity 59 (CAS CATO-C4X-101959)
- Fluconazole Impurity 39 (CAS CATO-C4X-101939)
- Fluconazole EP Impurity G (R-Isomer) (CAS CATO-C4X-101965)
- Fluconazole Impurity 18 (CAS 383127-79-5)
- Fluconazole Impurity 28 (CAS CATO-C4X-101928)
- Fluconazole Impurity 29 (CAS CATO-C4X-101929)
- Fluconazole Impurity 40 (CAS 206050-23-9)
Recommended Standards
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