N-Nitroso paroxetine impurity B CAS CATO-C4X-103580
| CAS No. | CATO-C4X-103580 |
| Molecular Formula | 2*C19H20N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, N-Nitroso paroxetine impurity B (CAS CATO-C4X-103580, C19H20N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of N-Nitroso paroxetine impurity B (C19H20N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C19H20N2O4 |
| Molecular Weight | 340.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related N Standards
- N-Nitroso Moexipril (CAS 1026879-47-9)
- N-Nitroso-N-Benzyl Anthranilic Acid (CAS 1028-91-7)
- N-Nitroso-2-Methylthiazolidine-4-Carboxylic Acid (CAS 103659-08-1)
- N-Nitroso Fexofenadine EP Impurity E (CAS 1038-06-8)
- N-Nitroso-N-methyl-3-aminopropionic Acid (CAS 10478-42-9)
- N-Nitroso Akardite II (CAS 1076199-26-2)
- N-Nitroso Thiamazole EP Impurity A (CAS 111348-65-3)
- N-Nitroso-Diethanolamine (CAS 1116-54-7)
Recommended Standards
- Entecavir Impurity 63 (CAS CATO-C4X-107763)
- Nicardipine Impurity 27 (CAS CATO-C4X-171027)
- Menaquinone impurity 26 (CAS CATO-C4X-207626)
- 1-(2-Fluoroethyl)-1H-1,2,4-triazole (CAS 265643-99-0)
- 2-(1H-1,2,3-benzotriazol-1-yloxy)acetic acid (CAS 639475-09-5)
- 2-(Piperidin-4-yloxy)nicotinic acid (CAS 1086392-90-6)
- 3-(2-Pyridyl)piperidine-3-carbonitrile (CAS 1909318-92-8)
- Rimegepant Impurity 30 (CAS CATO-C4X-248730)
- (2R,4S)-4-hydroxypyrrolidine-2-carbonitrile (CAS 2306252-36-6)
- Insulin Degludec Impurity 13 (CAS CATO-C4X-215713)
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