Trelagliptin impurity 85 CAS CATO-C4X-104685
| CAS No. | CATO-C4X-104685 |
| Molecular Formula | C18H20FN5O3 |
| Molecular Weight | 373.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Trelagliptin impurity 85 (CAS CATO-C4X-104685), a pharmacopoeial impurity reference standard (molecular formula C18H20FN5O3, MW 373.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Trelagliptin impurity 85 (C18H20FN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20FN5O3 |
| Molecular Weight | 373.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Trelagliptin Standards
- Trelagliptin Impurity 67 (CAS CATO-C4X-104667)
- Trelagliptin impurity 84 (CAS CATO-C4X-104684)
- Trelagliptin Impurity 9 (CAS 1938080-44-4)
- Trelagliptin Impurity 29 (CAS 1917324-15-2)
- Trelagliptin Impurity 40 (CAS CATO-C4X-104640)
- Trelagliptin-13C-d3 (CAS 2707203-34-5)
- Trelagliptin-13C-d3 (CAS 865759-25-7 (unlabelled))
- Trelagliptin Impurity 73 (CAS CATO-C4X-104673)
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