Regorafenib Impurity 46 CAS CATO-C4X-104746
| CAS No. | CATO-C4X-104746 |
| Molecular Formula | C19H15FN4O4 |
| Molecular Weight | 382.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 382.35 g/mol gives Regorafenib Impurity 46 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Regorafenib Impurity 46 (CAS CATO-C4X-104746), a pharmacopoeial impurity reference standard (molecular formula C19H15FN4O4, MW 382.35 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Regorafenib Impurity 46 (C19H15FN4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Regorafenib Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H15FN4O4 |
| Molecular Weight | 382.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Regorafenib Standards
- Regorafenib Impurity 41 (CAS CATO-C4X-104741)
- Regorafenib Impurity 74 (CAS CATO-C4X-104774)
- Regorafenib Impurity 38 (CAS CATO-C4X-104738)
- Regorafenib EP Impurity C (CAS 1855006-12-0)
- Regorafenib Impurity 19 (CAS 2098799-12-1)
- Regorafenib Impurity 53 (CAS CATO-C4X-104753)
- Regorafenib Impurity 81 (CAS CATO-C4X-104781)
- Regorafenib Impurity 45 (CAS CATO-C4X-104745)
Recommended Standards
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com