Regorafenib Impurity 74 CAS CATO-C4X-104774
| CAS No. | CATO-C4X-104774 |
| Molecular Formula | C19H15FN4O4 |
| Molecular Weight | 382.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Regorafenib Impurity 74 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Regorafenib Impurity 74 (CAS CATO-C4X-104774), a pharmacopoeial impurity reference standard (molecular formula C19H15FN4O4, MW 382.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C19H15FN4O4, Regorafenib Impurity 74 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 382.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H15FN4O4 |
| Molecular Weight | 382.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Regorafenib Standards
- Regorafenib Impurity 41 (CAS CATO-C4X-104741)
- Regorafenib Impurity 46 (CAS CATO-C4X-104746)
- Regorafenib Impurity 38 (CAS CATO-C4X-104738)
- Regorafenib EP Impurity C (CAS 1855006-12-0)
- Regorafenib Impurity 19 (CAS 2098799-12-1)
- Regorafenib Impurity 53 (CAS CATO-C4X-104753)
- Regorafenib Impurity 81 (CAS CATO-C4X-104781)
- Regorafenib Impurity 45 (CAS CATO-C4X-104745)
Recommended Standards
- Cefazolin EP Impurity D(Cefazolin USP RC J) (CAS 32510-61-5)
- 1,1,1-Trifluoro-N-(3-(quinolin-2-ylmethoxy)phenyl)methanesulfonamide (CAS 111974-60-8)
- 4-Methoxy-3-[(2-methoxy-5-nitrophenyl)sulfamoyl]benzoic acid (CAS 750613-71-9)
- Methyl 3-O-feruloylquinate (CAS 154418-15-2)
- Benvitimod impurity 6 (CAS CATO-C4X-24456)
- Hydroxychloroquine impurity 86 (CAS CATO-C4X-183586)
- Iguratimod Impurity 31 (CAS CATO-C4X-182631)
- 2-methyl-2H-indazole-6-carboxylic acid (CAS 1031417-46-5)
- piperidin-2-ylmethyl piperidine-1-carboxylate hydrochloride (CAS 1803601-95-7)
- {1-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperidin-4-yl}methanol (CAS 1202805-30-8)
- 1-((4-Fluorophenyl)sulfonyl)pyrrolidine-3-carboxylic acid (CAS 1171916-98-5)
- 2-C-Methylguanosine (CAS 374750-30-8)
- 5-((6-(Methyl(tetrahydro-2H-pyran-3-yl)amino)pyrimidin-4-yl)amino)pyrazine-2-carbonitrile (CAS 1137475-44-5)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com