Ceritinib Impurity 4 CAS CATO-C4X-10484
| CAS No. | CATO-C4X-10484 |
| Molecular Formula | C25H30ClN5O3S |
| Molecular Weight | 516.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ceritinib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Ceritinib Impurity 4 (CAS CATO-C4X-10484) is a certified pharmaceutical impurity reference standard with the molecular formula C25H30ClN5O3S and a molecular weight of 516.06 g/mol.
Ceritinib Impurity 4 (C25H30ClN5O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H30ClN5O3S |
| Molecular Weight | 516.06 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Ceritinib Standards
- Ceritinib Impurity 3 (CAS CATO-C4X-10483)
- Ceritinib Impurity 54 (CAS CATO-C4X-104854)
- Ceritinib Impurity 5 (CAS CATO-C4X-10485)
- Ceritinib Impurity 62 (CAS CATO-C4X-104862)
- Ceritinib Impurity 12 (CAS CATO-C4X-104812)
- Ceritinib Impurity 15 (CAS CATO-C4X-1048915)
- Ceritinib Impurity 11 (CAS CATO-C4X-104811)
- Ceritinib Impurity 27 (CAS CATO-C4X-104827)
Recommended Standards
- TP-0903 (CAS 1341200-45-0)
- 3,3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]methylene]bis(thio)]bis-propanoic Acid 1,1-Dimethyl Ester (CAS 120385-96-8)
- LP99 (CAS 1808951-93-0)
- (2S,3S)-2,3-Bis((4-bromobenzoyl)oxy)succinic acid (CAS 391624-83-2)
- Furosemide Impurity 54 (CAS 33069-75-9)
- Ceftizoxime Impurity 93 (CAS CATO-C4X-179393)
- Rosuvastatin Impurity 238 (CAS CATO-C4X-1169238)
- 5-Bromo-2-chloro-1-fluoro-3-methylbenzene (CAS 1806971-86-7)
- 423739-52-0 2-(4-chlorophenyl)-N-(4-ethoxybenzyl)ethanamine DTXSID00365823 (CAS 423739-52-0)
- Orphenadrine EP Impurity A (CAS 5472-13-9)
- 4-(3,5-Dimethyl-1H-pyrazole-1-carbonyl)-N-(4-ethylphenyl)-1H-pyrazole-5-sulfonamide (CAS 1106778-22-6)
- 2,4-Dichlorobenzamide (CAS 2447-79-2)
- Methyl L-leucinate (CAS 2666-93-5)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
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