Ceritinib Impurity 45 CAS CATO-C4X-104845
| CAS No. | CATO-C4X-104845 |
| Molecular Formula | C22H26N2O3 |
| Molecular Weight | 366.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Ceritinib Impurity 45 (CAS CATO-C4X-104845) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26N2O3 and a molecular weight of 366.45 g/mol.
The molecular framework of Ceritinib Impurity 45 (C22H26N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H26N2O3 |
| Molecular Weight | 366.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Ceritinib Standards
- Ceritinib Impurity 39 (CAS CATO-C4X-104839)
- Ceritinib Impurity 43 (CAS CATO-C4X-104843)
- Ceritinib Impurity 48 (CAS CATO-C4X-104848)
- Ceritinib Impurity 55 (CAS CATO-C4X-104855)
- Ceritinib Impurity 26 (CAS CATO-C4X-104826)
- Ceritinib Impurity 10 (CAS CATO-C4X-1048910)
- Ceritinib Impurity 16 (CAS CATO-C4X-1048916)
- Ceritinib Impurity 58 (CAS CATO-C4X-104858)
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