Ceritinib Impurity 26 CAS CATO-C4X-104826
| CAS No. | CATO-C4X-104826 |
| Molecular Formula | C13H13BrClN3S |
| Molecular Weight | 358.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ceritinib Impurity 26.
As a process- or degradation-related impurity, Ceritinib Impurity 26 (CAS CATO-C4X-104826, C13H13BrClN3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ceritinib Impurity 26 (C13H13BrClN3S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 358.68 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ceritinib Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13BrClN3S |
| Molecular Weight | 358.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Ceritinib Standards
- Ceritinib Impurity 16 (CAS CATO-C4X-1048916)
- Ceritinib Impurity 58 (CAS CATO-C4X-104858)
- Ceritinib Impurity 56 (CAS CATO-C4X-104856)
- Ceritinib Impurity 39 (CAS CATO-C4X-104839)
- Ceritinib Impurity 43 (CAS CATO-C4X-104843)
- Ceritinib Impurity 45 (CAS CATO-C4X-104845)
- Ceritinib Impurity 48 (CAS CATO-C4X-104848)
- Ceritinib Impurity 55 (CAS CATO-C4X-104855)
Recommended Standards
- 3-Chloro-5-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole (CAS 2761197-19-5)
- N-(2-Chlorobenzyl)-4-(2,4-dichlorophenoxy)-1-butanamine (CAS 1040684-21-6)
- Perfluorophenyl 2-chlorobenzenesulfonate (CAS 885949-55-3)
- 2,2,4,4,6,6,8-Heptamethyl-8-phenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane (CAS 10448-09-6)
- Arginine Impurity 17 (CAS 151512-14-0)
- Ciprofibrate EP Impurity E (CAS 52179-28-9)
- Iguratimod Impurity 76 (CAS CATO-C4X-182676)
- (E)-4-(2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid (CAS 166977-43-1)
- 4-Amino-2-chloro-6-methyl-5-nitropyrimidine (CAS 5453-06-5)
- Nicorandil Impurity 55 (CAS 3612-79-1)
- Lovastatin Anhydro Acid Sodium Salt (CAS 188067-71-2)
- Ethyl 4-(aminomethyl)benzoate (CAS 366-84-7)
- 8,10-Dibromo-5,6-dihydro-2,4-dimethyl-4H-benzo[b]furo[3′,2′:6,7]cyclohepta[1,2-d]furan (CAS 220542-74-5)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
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