Topiroxostat impurity 74 CAS CATO-C4X-105574
| CAS No. | CATO-C4X-105574 |
| Molecular Formula | C6H8N4 |
| Molecular Weight | 136.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Topiroxostat impurity 74 (C6H8N4) is characterized by a nitrile group, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Topiroxostat impurity 74 (CAS CATO-C4X-105574, C6H8N4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8N4 |
| Molecular Weight | 136.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Topiroxostat Standards
- Topiroxostat Impurity 33 (CAS 89830-71-7)
- Topiroxostat Impurity 36 (CAS 35451-46-8)
- Topiroxostat Impurity 4 (CAS 2459-09-8)
- Topiroxostat Impurity 47 (CAS 93-60-7)
- Topiroxostat Impurity 6 (CAS 54-85-3)
- Topiroxostat Impurity 3 (CAS 13602-12-5)
- Topiroxostat Impurity 46 (CAS 29181-50-8)
- Topiroxostat Impurity 51 (CAS 98273-47-3)
Recommended Standards
- Regorafenib Impurity 54 (CAS 6843-37-4)
- Imatinib Impurity 63 (CAS 99-94-5)
- Formic acid-benzyl ester (CAS 104-57-4)
- Sorafenib Impurity 24 (CAS 6144-78-1)
- Cloxacillin Impurity 32 (CAS CATO-C4X-159732)
- Tiotropium Bromide Impurity 17 (CAS CATO-C4X-176417)
- Uridine Impurity 23 (CAS CATO-C4X-233423)
- N-((tert-Butyldimethylsilyl)oxy)-4-methylbenzenesulfonamide (CAS 1028432-04-3)
- 8-Bromo-2-chloroimidazo[1,2-b]pyridazine-7-carboxylic acid (CAS 2577171-57-2)
- 2,6-Dichloro-7-(2-(chloromethyl)benzyl)-7H-purine (CAS 924904-10-9)
- N-(2-(1H-Indol-1-yl)ethyl)heptadecanamide (CAS 232257-97-5)
- (2-Methyl-4-(2-methylpiperidin-1-yl)phenyl)boronic acid (CAS 2225152-53-2)
- Methyl 3-methyl-2-naphthoate (CAS 50915-65-6)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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