Valsartan Impurity 80 TriHCl CAS CATO-C4X-105780
| CAS No. | CATO-C4X-105780 |
| Molecular Formula | C33H31N9O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Valsartan Impurity 80 TriHCl (CAS CATO-C4X-105780, C33H31N9O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Valsartan Impurity 80 TriHCl (C33H31N9O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Valsartan Impurity 80 TriHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H31N9O2 3*HCl |
| Molecular Weight | 622.13 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 22.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 9 |
Related Valsartan Standards
- Valsartan Impurity 121 (CAS 1000986-63-9)
- (S)-(-)-Valsartan-d8 (valine-d8) (CAS 1089736-72-0)
- Valsartan-d9 (Major) (CAS 1089736-73-1)
- Valsartan Impurity 13 ( Valproic Acid EP Impurity A ) (CAS 109-52-4)
- Valsartan Impurity 35 HCl (CAS 1111177-20-8)
- Valsartan Impurity 9 (CAS 1111177-30-0)
- Valsartan Impurity 10 (CAS 114772-54-2)
- Valsartan Impurity 82 (CAS 1189547-11-2)
Recommended Standards
- Tofacitinib Impurity 17 (CAS 1675248-19-7)
- Lercanidipine Impurity 75 (CAS CATO-C4X-136475)
- Perindopril Impurity 32 (CAS CATO-C4X-125232)
- 4,4-Dibromo-2,6-di-tert-butylcyclohexa-2,5-dienone (CAS 1144-36-1)
- Ceftazidime Impurity 111 (CAS CATO-C4X-1212111)
- 4-(3-Cyanophenyl)-2-fluorobenzonitrile (CAS 1393441-82-1)
- Stipuleanoside R2 (CAS 96627-72-4)
- 5-Bromo-3-(chlorosulfonyl)-2-fluorobenzoic acid (CAS 926251-51-6)
- Methyl (furan-2-ylmethyl)-L-prolinate (CAS 946409-42-3)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
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