Cinacalcet Impurity 66 CAS CATO-C4X-105966
| CAS No. | CATO-C4X-105966 |
| Molecular Formula | C22H21F3NO |
| Molecular Weight | 372.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Cinacalcet Impurity 66 (CAS CATO-C4X-105966), a pharmacopoeial impurity reference standard (molecular formula C22H21F3NO, MW 372.40 g/mol) used for the identification and quantification of trace impurities in APIs.
Cinacalcet Impurity 66 (C22H21F3NO) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H21F3NO |
| Molecular Weight | 372.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cinacalcet Standards
- Cinacalcet impurity 88 (CAS CATO-C4X-105988)
- Cinacalcet Impurity N52 (CAS 1005450-55-4)
- Cinacalcet Impurity 41 (CAS CATO-C4X-105941)
- Cinacalcet Impurity 42 (CAS CATO-C4X-105942)
- Cinacalcet Impurity 43 (CAS CATO-C4X-105943)
- Cinacalcet Impurity 44 (CAS CATO-C4X-105944)
- Cinacalcet N-Oxide (CAS 1229224-94-5)
- Cinacalcet Impurity 81 (CAS CATO-C4X-105981)
Recommended Standards
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