Bromhexine Impurity 37 CAS CATO-C4X-106037
| CAS No. | CATO-C4X-106037 |
| Molecular Formula | C20H30Br2N2O5 |
| Molecular Weight | 538.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bromhexine Impurity 37.
CATO supplies Bromhexine Impurity 37 (CAS CATO-C4X-106037), a pharmacopoeial impurity reference standard (molecular formula C20H30Br2N2O5, MW 538.27 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Bromhexine Impurity 37 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 538.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H30Br2N2O5 |
| Molecular Weight | 538.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bromhexine Standards
- Bromhexine D-Glucose Derivative (CAS CATO-C4X-106021)
- Bromhexine Impurity 26 (CAS CATO-C4X-106026)
- Bromhexine Impurity 31 (CAS CATO-C4X-106031)
- Bromhexine L-Glucose Derivative(Mixture of Diastereomers) (CAS CATO-C4X-106032)
- Bromhexine Impurity 64 (CAS CATO-C4X-106064)
- Bromhexine impurity 65 (CAS CATO-C4X-106065)
- Bromhexine impurity 67 (CAS CATO-C4X-106067)
- Bromhexine L-Glucose Derivative (CAS CATO-C4X-106043)
Recommended Standards
- Fluralaner Impurity 56 (CAS CATO-C4X-218056)
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- N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)benzenesulfonamide (CAS 331972-29-3)
- Bis-PEG2-PFP ester (CAS 1314378-18-1)
- Mirogabalin Impurity 80 (CAS CATO-C4X-292480)
- Lotilaner Impurity 4 (CAS CATO-C4X-32564)
- Bumetanide impurity 106 (CAS CATO-C4X-1986106)
- 4-(3-Fluorophenoxy)butanethioamide (CAS 1016814-63-3)
- 5-(pyrrolidin-2-yl)-1,2,4-oxadiazole-3-carboxamide hydrochloride (CAS 1795344-84-1)
- (1R,2R)-2-methoxycyclohexanamine;hydrochloride (CAS 2375165-94-7)
- 4-[(furan-2-ylmethyl)sulfamoyl]-1-methyl-1h-pyrrole-2-carboxylic acid (CAS 937609-07-9)
- 3-Bromo-2-methoxybenzonitrile (CAS 874472-98-7)
- 5-((4-(tert-Butyl)-2-chlorophenoxy)methyl)-1,3,4-oxadiazol-2-amine (CAS 1706452-11-0)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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