Ibrutinib Impurity 8 CAS CATO-C4X-10648
| CAS No. | CATO-C4X-10648 |
| Molecular Formula | C25H26N6O2 |
| Molecular Weight | 442.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ibrutinib Impurity 8 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ibrutinib Impurity 8 (CAS CATO-C4X-10648), a pharmacopoeial impurity reference standard (molecular formula C25H26N6O2, MW 442.51 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C25H26N6O2, Ibrutinib Impurity 8 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 442.51 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H26N6O2 |
| Molecular Weight | 442.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 2 (CAS 1839099-22-7)
- Ibrutinib Impurity 170 (CAS CATO-C4X-1064170)
- Ibrutinib Impurity 78 (CAS 2031255-24-8)
- Ibrutinib Racemate (CAS 936563-87-0)
- Ibrutinib (CAS 936563-96-1)
- Ibrutinib Impurity 1 (CAS 936563-97-2)
- Ibrutinib Impurity 20 (CAS 936563-92-7)
- Ibrutinib Impurity 40 (CAS CATO-C4X-106440)
Recommended Standards
- AZD-9291 Impurity 7 (CAS 2044702-39-6)
- N5-((S)-4-Amino-1-carboxybutyl)-L-glutamine (CAS 56523-61-6)
- Telmisartan Impurity 47 (CAS 884330-11-4)
- Methyl (1R,2R)-2-(4'-(3-phenylureido)-[1,1'-biphenyl]-4-carbonyl)cyclopentane-1-carboxylate (CAS 959122-10-2)
- Rivaroxaban impurity 168 (CAS CATO-C4X-1090168)
- Cefotaxime Impurity 98 (CAS CATO-C4X-120198)
- Tenofovir disoproxil Impurity 131 (CAS CATO-C4X-1076131)
- 1,5-Pentanediol diacrylate (stabilized with MEHQ) (CAS 36840-85-4)
- 4-(5-Methoxy-1H-indol-1-yl)aniline (CAS 1708380-55-5)
- 2-(3-Hydroxypyrrolidin-1-yl)ethanethioamide (CAS 1339885-07-2)
- (S)-tert-Butyl (1-(((6-chloropyridin-3-yl)methyl)(methyl)amino)-1-oxopropan-2-yl)carbamate (CAS 1421033-13-7)
- 2-(Benzo[4,5]thiazolo[2,3-c][1,2,4]triazol-3-ylthio)-1-(4-methylpiperidin-1-yl)ethan-1-one (CAS 374693-57-9)
- N-(4-(2-Methyl-1H-benzo[d]imidazol-1-yl)pyridin-3-yl)acetamide (CAS 183547-90-2)
- Semaglutide impurity 251 (CAS CATO-C4X-2226251)
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