Empagliflozin Impurity 136 CAS CATO-C4X-1065136
| CAS No. | CATO-C4X-1065136 |
| Molecular Formula | C17H16Br2O2 |
| Molecular Weight | 412.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Empagliflozin Impurity 136 is closely related to a steroid core, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Empagliflozin Impurity 136 (CAS CATO-C4X-1065136), a pharmacopoeial impurity reference standard (molecular formula C17H16Br2O2, MW 412.12 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Empagliflozin Impurity 136 (C17H16Br2O2) contains a steroid core, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 412.12 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Empagliflozin Impurity 136 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H16Br2O2 |
| Molecular Weight | 412.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 190 (CAS CATO-C4X-1065190)
- Empagliflozin Impurity 111 (CAS 2194590-02-6)
- Empagliflozin Impurity 113 (CAS 2452301-16-3)
- Empagliflozin Impurity 21 (CAS CATO-C4X-106521)
- Empagliflozin impurity 61 (CAS CATO-C4X-1065261)
- Empagliflozin impurity 265 (CAS CATO-C4X-1065265)
- Empagliflozin impurity 320 (CAS CATO-C4X-1065320)
- Empagliflozin Impurity 41 (CAS CATO-C4X-106541)
Recommended Standards
- 9,10-Dibromo-2-phenylanthracene (CAS 929103-26-4)
- Indium(III) acetylacetonate (CAS 14405-45-9)
- 2,8-Dibromo-6,12-dihydroindeno[1,2-b]fluorene (CAS 848982-57-0)
- Tert-butyl (4-cyano-2-iodo-5-(trifluoromethyl)phenyl)carbamate (CAS 1190198-36-7)
- Azathioprine Impurity 25 (CAS CATO-C4X-146325)
- Etomidate Impurity 50 (CAS 2626887-15-6)
- Finerenone Impurity 88 (CAS CATO-C4X-288088)
- 4-(Aminomethyl)-n-[2-(diethylamino)ethyl]benzamide dihydrochloride (CAS 1171137-83-9)
- 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 1-((4-chlorophenyl)sulfonyl)piperidine-4-carboxylate (CAS 853596-29-9)
- tert-Butyl 4-hydroxy-3-iodo-1H-indazole-1-carboxylate (CAS 1822856-55-2)
- 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide (CAS 1082745-50-3)
- Ethyl (1-methyl-6-oxo-1,6-dihydropyridin-3-yl)carbamate (CAS 858839-71-1)
- 5-Aminoimidazo[1,2-a]pyridine-3-carbaldehyde (CAS 35220-26-9)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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