Axitinib Impurity 61 CAS CATO-C4X-107161
| CAS No. | CATO-C4X-107161 |
| Molecular Formula | C14H8I2N4 |
| Molecular Weight | 486.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Axitinib Impurity 61 (CAS CATO-C4X-107161) is a certified pharmaceutical impurity reference standard with the molecular formula C14H8I2N4 and a molecular weight of 486.05 g/mol.
Axitinib Impurity 61 (C14H8I2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, iodine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Axitinib Impurity 61 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H8I2N4 |
| Molecular Weight | 486.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 4 |
Related Axitinib Standards
- Axitinib Impurity 4 (CAS 1443118-72-6)
- Axitinib Impurity 22 (CAS CATO-C4X-107122)
- Axitinib Impurity 11 (CAS 885126-35-2)
- Axitinib Impurity 56 (CAS 2690338-63-5)
- Axitinib Impurity 16 (CAS CATO-C4X-107116)
- Axitinib Impurity 31 (CAS CATO-C4X-107131)
- Axitinib Impurity 62 (CAS CATO-C4X-107162)
- Axitinib Impurity 75 (CAS CATO-C4X-107175)
Recommended Standards
- Benzenepropanoic acid, 3-(5-chloro-2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxy-, 2-ethylhexyl ester (CAS 83044-90-0)
- WGL8B3MDAS 7224-08-0 Imiclopazine Imiclopazine [INN] 1-(2-(4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl)-3-methyl-2-imidazolidinone 1-(2-(4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl)-3-methyl-2-imidazolidinone Imiclopazina [INN-Spanish] Imiclopazinum [INN-Latin] Imiclopazina Imiclopazinum UNII-WGL8B3MDAS (CAS 7224-08-0)
- Nefazodone Impurity 6 (CAS 98159-82-1)
- rel-Tetraisopropyl (4R,4'R,5R,5'R)-[2,2'-bi(1,3,2-dioxaborolane)]-4,4',5,5'-tetracarboxylate (CAS 480438-21-9)
- Clofazimine Impurity 6 (CAS CATO-C4X-20716)
- Doxapram Impurity 26 HCl (CAS CATO-C4X-197326)
- Flurbiprofen Impurity 84 (CAS 5001-96-7)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-indazole-3-carbaldehyde (CAS 2166086-40-2)
- 5,6-Dichloro-2-isopropylnicotinonitrile (CAS 1707581-46-1)
- 2,5-Dibromo-3,4-dinitrothiophene (CAS 52431-30-8)
- 5-Methyl-2-phenoxyaniline hydrochloride (CAS 166100-79-4)
- 2-(1,2-Oxazol-4-yl)ethan-1-amine hydrochloride (CAS 1187928-51-3)
- 2-(4-Methoxyphenyl)-7-methylquinoline-4-carboxylic acid (CAS 116734-21-5)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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