Axitinib Impurity 16 CAS CATO-C4X-107116
| CAS No. | CATO-C4X-107116 |
| Molecular Formula | C21H15IN4 |
| Molecular Weight | 450.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Axitinib Impurity 16 (CAS CATO-C4X-107116) is a certified pharmaceutical impurity reference standard with the molecular formula C21H15IN4 and a molecular weight of 450.28 g/mol.
The molecular framework of Axitinib Impurity 16 (C21H15IN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Axitinib Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H15IN4 |
| Molecular Weight | 450.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 4 |
Related Axitinib Standards
- Axitinib Impurity 31 (CAS CATO-C4X-107131)
- Axitinib Impurity 62 (CAS CATO-C4X-107162)
- Axitinib Impurity 75 (CAS CATO-C4X-107175)
- Axitinib Impurity 33 (CAS CATO-C4X-107133)
- Axitinib Impurity 34 (CAS CATO-C4X-107134)
- Axitinib Impurity 78 (CAS CATO-C4X-107178)
- Axitinib Impurity 24 (CAS CATO-C4X-107124)
- Axitinib Impurity 12 (CAS 886230-77-9)
Recommended Standards
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- 5-Amino-1-(2-(2-hydroxyethoxy)ethyl)-4-methylpyridin-2(1h)-one (CAS 1525759-55-0)
- (SP-5-14)-[N-[2-[Bis(1,1-dimethylethyl)phosphino-κP]ethyl]-2-pyridinemethanamine-κN1,κN2]dichlorocobalt (CAS 1950613-91-8)
- 3-(4-fluorophenyl)oxolane-2,5-dione (CAS 630067-33-3)
- N-(2,5-Dimethylphenyl)quinoline-2-carbothioamide (CAS 430469-78-6)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com