Axitinib Impurity 81 CAS CATO-C4X-107181
| CAS No. | CATO-C4X-107181 |
| Molecular Formula | C24H24I2N4O2 |
| Molecular Weight | 654.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Axitinib Impurity 81 (CAS CATO-C4X-107181, C24H24I2N4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H24I2N4O2, Axitinib Impurity 81 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 654.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Axitinib Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H24I2N4O2 |
| Molecular Weight | 654.28 g/mol |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 4 |
Related Axitinib Standards
- Axitinib Impurity 57 (CAS CATO-C4X-107157)
- Axitinib Impurity 42 (CAS 808142-24-7)
- Axitinib Impurity 30 (CAS CATO-C4X-107130)
- Axitinib Impurity 67 (CAS CATO-C4X-107167)
- Axitinib Impurity 6 (CAS 1428728-83-9)
- Axitinib Impurity 82 (CAS CATO-C4X-107182)
- Axitinib Impurity N2 (CAS 1428728-84-0)
- Axitinib Impurity 56 (CAS 2690338-63-5)
Recommended Standards
- Arabino-Hexos-2-ulose, bis[[[[(4-ethoxyphenyl)methyl]amino]thioxomethyl]hydrazone], copper complex (CAS 95148-33-7)
- 2,6-Bis(3,5-dichlorophenyl)-4-hydroxydinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-sulfide (CAS 1706463-50-4)
- Fmoc-His(Clt)-OH (CAS 224032-19-3)
- Bedaquiline Impurity 66 (CAS 1245907-31-6)
- Amlodipine Impurity 117 (CAS CATO-C4X-1095117)
- Belzutifan Impurity 2 (CAS CATO-C4X-33942)
- Clopidogrel Impurity 30 (CAS 212838-70-5)
- 2-((4-Ethylcyclohexyl)amino)butan-1-ol (CAS 1152688-02-2)
- 5-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]amino]pentanal (CAS 2504915-12-0)
- 2-(Cyclopropylethynyl)-4-nitroaniline (CAS 952664-83-4)
- 1-{3-[4-(4-chlorophenyl)piperazin-1-yl]-5-(trifluoromethyl)pyridin-2-yl}ethan-1-one (CAS 900015-68-1)
- 2-Ethyl-N-((1-(4-fluorophenyl)-1H-tetrazol-5-yl)methyl)butanamide (CAS 897623-34-6)
- Methanesulfonamide, N-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-1,1,1-trifluoro-, compd. with N,N-diethylethanamine (1:1) (CAS 1150111-92-4)
- Semaglutide impurity 206 (CAS CATO-C4X-2226206)
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