Tofacitinib Impurity 76 CAS CATO-C4X-107976
| CAS No. | CATO-C4X-107976 |
| Molecular Formula | C15H21N5O |
| Molecular Weight | 287.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tofacitinib Impurity 76 (CAS CATO-C4X-107976, C15H21N5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H21N5O, Tofacitinib Impurity 76 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 287.36 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H21N5O |
| Molecular Weight | 287.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 12 (CAS 477600-76-3)
- Tofacitinib Impurity 75 (CAS CATO-C4X-107975)
- Tofacitinib Impurity 68 (CAS CATO-C4X-107968)
- Tofacitinib Impurity 160 (CAS CATO-C4X-1079160)
- Tofacitinib Nitroso Impurity 190 (CAS CATO-C4X-1079190)
- Tofacitinib Impurity 33 (CAS 1640971-60-3)
- Tofacitinib Impurity 59 (CAS 2250241-69-9)
- Tofacitinib Nitroso Impurity 191 (CAS CATO-C4X-1079191)
Recommended Standards
- Zolmitriptan (CAS 139264-17-8)
- Zolmitriptan EP Impurity A (CAS 139264-24-7)
- tert-Butyl 6-amino-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (CAS 313369-40-3)
- Zolmitriptan Impurity 31 (CAS CATO-C4X-135131)
- Cefotaxime Impurity 35 (CAS CATO-C4X-120135)
- Canagliflozin Impurity 50 (CAS CATO-C4X-112350)
- Osimertinib Impurity 61 (CAS CATO-C4X-204561)
- (4-Iodophenyl)(phenyl)phosphinicacid (CAS 54185-74-9)
- (S)-2-Amino-3-(benzo[d][1,3]dioxol-4-yl)propanoic acid (CAS 1269980-63-3)
- N-(4-Methoxybenzo[d]thiazol-2-yl)-1-methyl-1H-pyrazole-3-carboxamide (CAS 1020489-07-9)
- 2-[-N-(2-Cyanoethyl)-4-[(p-nitrophenyl)azo]anilino]ethylbenzoate (CAS 40690-89-9)
- Methyl 5-(methylthio)-4-phenyl-3-(1H-pyrrol-1-yl)thiophene-2-carboxylate (CAS 947598-69-8)
- Ethyl (2-((2-chloropyridin-3-yl)amino)-1,1,1,3,3,3-hexafluoropropan-2-yl)carbamate (CAS 340033-55-8)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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