Tofacitinib Impurity 12 CAS 477600-76-3
| CAS No. | 477600-76-3 |
| Molecular Formula | C15H21N5O |
| Molecular Weight | 287.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tofacitinib Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Tofacitinib Impurity 12 (CAS 477600-76-3) is a certified pharmaceutical impurity reference standard with the molecular formula C15H21N5O and a molecular weight of 287.36 g/mol.
The molecular framework of Tofacitinib Impurity 12 (C15H21N5O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H21N5O |
| Molecular Weight | 287.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 75 (CAS CATO-C4X-107975)
- Tofacitinib Impurity 76 (CAS CATO-C4X-107976)
- Tofacitinib Impurity 68 (CAS CATO-C4X-107968)
- Tofacitinib Impurity 160 (CAS CATO-C4X-1079160)
- Tofacitinib Nitroso Impurity 190 (CAS CATO-C4X-1079190)
- Tofacitinib Impurity 33 (CAS 1640971-60-3)
- Tofacitinib Impurity 59 (CAS 2250241-69-9)
- Tofacitinib Nitroso Impurity 191 (CAS CATO-C4X-1079191)
Recommended Standards
- tert-Butyl 6-amino-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (CAS 313369-40-3)
- tert-Butyl 4-(5-ethynylpyridin-2-yl)piperazine-1-carboxylate (CAS 497915-48-7)
- tert-Butyl 4-(3-Cyanophenyl)piperazine-1-carboxylate (CAS 807624-20-0)
- Zolmitriptan (CAS 139264-17-8)
- Rifabutin Impurity 14 (CAS CATO-C4X-251214)
- Olaparib Impurity 16 (CAS 848136-41-4)
- Brexpiprazole Impurity 7 (CAS 913613-82-8)
- Himbacine (CAS 6879-74-9)
- N-(4-bromophenyl)-2-chloronicotinamide (CAS 56149-25-8)
- Glycopyrronium Bromide Impurity 13 (CAS CATO-C4X-181713)
- Fmoc-hydrazine (CAS 35661-51-9)
- 6-Chloro-7-(chloromethyl)-2,3-dihydro-1,4-benzodioxine (CAS 1094400-29-9)
- (3,5-Dimethylphenyl)(oxazol-2-yl)methanone (CAS 898784-52-6)
- Acetyl Tetrapeptide- 15 (CAS 928007-64-1)
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