Diacerein Impurity 27 CAS CATO-C4X-108127
| CAS No. | CATO-C4X-108127 |
| Molecular Formula | C15H8Cl2O3 |
| Molecular Weight | 307.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 307.13 g/mol gives Diacerein Impurity 27 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Diacerein Impurity 27 (CAS CATO-C4X-108127, C15H8Cl2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Diacerein Impurity 27 (C15H8Cl2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Diacerein Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H8Cl2O3 |
| Molecular Weight | 307.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Diacerein Standards
- Diacerein Impurity 15 (CAS CATO-C4X-108115)
- Diacerein Impurity 16 (CAS CATO-C4X-108116)
- Diacerein Impurity 25 (CAS CATO-C4X-108125)
- Diacerein EP Impurity D (CAS 875535-35-6)
- Diacerein EP Impurity E (CAS 875535-36-7)
- Diacerein Impurity 22 (CAS CATO-C4X-108122)
- Diacerein Impurity 20 (CAS 159898-12-1)
- Diacerein Impurity 18 (CAS 154658-30-7)
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