Ibuprofen impurity 137 CAS CATO-C4X-1082137
| CAS No. | CATO-C4X-1082137 |
| Molecular Formula | C22H29NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ibuprofen impurity 137 (C22H29NO3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Ibuprofen impurity 137 (CAS CATO-C4X-1082137) is a certified pharmaceutical impurity reference standard with the molecular formula C22H29NO3HCl and a molecular weight of 391.94 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ibuprofen impurity 137 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29NO3 HCl |
| Molecular Weight | 391.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ibuprofen Standards
- Ibuprofen Impurity 5 (CAS 100319-40-2)
- Ibuprofen EP Impurity R (CAS 102120-87-6)
- Ibuprofen Impurity 20 (CAS 10262-65-4)
- Ibuprofen Impurity 35 (CAS 103775-30-6)
- Ibuprofen impurity 127 (CAS 105959-56-6)
- Ibuprofen Methocarbamol Ester (Mixture of Diastereomers) (CAS 111632-17-8)
- Ibuprofen Impurity 42 (CAS 113403-10-4)
- Ibuprofen Acyl Glucuronide (Mixture of Diastereomers) (CAS 115075-59-7)
Recommended Standards
- Rivaroxaban Impurity 46 (CAS 1411775-06-8)
- Torasemide Impurity 25 (CAS CATO-C4X-183625)
- Mianserin impurity 29 (CAS 147086-11-1)
- 6-[(4-Fluorophenyl)sulfanyl]-9H-purin-2-amine (CAS 860650-66-4)
- tert-Butyl 3-((2-chloro-6-methylpyrimidin-4-yl)amino)piperidine-1-carboxylate (CAS 1261232-98-7)
- 5-((Ethylthio)methyl)pyrimidin-2-amine (CAS 37795-59-8)
- 7-Chloro-9-oxo-9H-fluorene-1-carboxylic acid (CAS 1673-28-5)
- 77901-50-9 [(2-Chlorophenyl)amino](oxo)acetic acid MFCD10018463 (CAS 77901-50-9)
- N-(3-methoxypropyl)tetrahydro-2H-pyran-4-amine (CAS 887589-01-7)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
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