Ibuprofen Impurity 66 CAS CATO-C4X-108266
| CAS No. | CATO-C4X-108266 |
| Molecular Formula | C22H29NO3 |
| Molecular Weight | 355.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ibuprofen Impurity 66.
Ibuprofen Impurity 66 (CAS CATO-C4X-108266) is a certified pharmaceutical impurity reference standard with the molecular formula C22H29NO3 and a molecular weight of 355.47 g/mol.
Structurally, Ibuprofen Impurity 66 (C22H29NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 355.47 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29NO3 |
| Molecular Weight | 355.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Ibuprofen Standards
- Ibuprofen impurity 128 (CAS CATO-C4X-1082128)
- Ibuprofen impurity 131 (CAS CATO-C4X-1082131)
- Ibuprofen impurity 133 (CAS CATO-C4X-1082133)
- Ibuprofen Impurity 62 (CAS CATO-C4X-108262)
- Ibuprofen Impurity 63 (CAS CATO-C4X-108263)
- Ibuprofen Impurity 87 (CAS CATO-C4X-108287)
- Ibuprofen Impurity 88（Mixture of Diastereoisomer） (CAS CATO-C4X-108288)
- Ibuprofen Impurity 116 (CAS CATO-C4X-1082116)
Recommended Standards
- Bisoprolol EP Impurity G (CAS 1215342-36-1)
- Phenylephrine Impurity 28(Mixture of Diastereomers) (CAS CATO-C4X-146728)
- Dienogest EP Impurity D (CAS 190662-30-7)
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- Mivacurium chloride Impurity 72 (CAS CATO-C4X-137572)
- Levocarnitine Impurity 16 (CAS 105-33-9)
- Trazodone Impurity 66 (CAS CATO-C4X-177266)
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- 3-Methyl-1-[(1r,4r)-4-hydroxycyclohexyl]urea (CAS 80413-65-6)
- 5-Bromo-2-chloro-4-(oxetan-3-yloxy)pyrimidine (CAS 1602823-78-8)
- 5-Methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (CAS 4318-54-1)
- 9H-Purine (CAS 51953-03-8)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
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