Apixaban Impurity 49 CAS CATO-C4X-108849
| CAS No. | CATO-C4X-108849 |
| Molecular Formula | C12H16ClNO2 |
| Molecular Weight | 241.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Apixaban Impurity 49 (CAS CATO-C4X-108849) is a certified pharmaceutical impurity reference standard with the molecular formula C12H16ClNO2 and a molecular weight of 241.71 g/mol.
Based on its molecular formula C12H16ClNO2, Apixaban Impurity 49 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 241.71 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Apixaban Impurity 49 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16ClNO2 |
| Molecular Weight | 241.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Apixaban Standards
- Apixaban impurity 01 (CAS 501-58-6)
- Apixaban Impurity 100 (CAS CATO-C4X-1088100)
- Apixaban Impurity 105 (CAS 70736-27-5)
- Apixaban Impurity 141 (CAS CATO-C4X-1088141)
- Apixaban Impurity 82 (CAS 2614-10-0)
- Apixaban Related Compound 1 (CAS 4792-57-8)
- Apixaban Impurity 42 (CAS 132577-23-2)
- Apixaban impurity 159 (CAS CATO-C4X-1088159)
Recommended Standards
- Baclofen impurity 12 (CAS 232597-00-1)
- Chlorphenamine Impurity 69 (CAS CATO-C4X-118869)
- 3-Chloro-2-(tetrahydro-2H-pyran-2-ylmethoxy)-phenylamine 4028AF 946682-29-7 C12H16ClNO2 (CAS 946682-29-7)
- Clomazone metabolite FMC 65317 (CAS 171569-37-2)
- Tazobactam Impurity 17 (CAS 115546-66-2)
- Tedizolid Impurity 15 (CAS 1700656-53-6)
- Gadobutrol Impurity 7 (CAS CATO-C4X-21207)
- Methyl 2-Chloro-4-fluorobenzoate (CAS 85953-29-3)
- Tolvaptan Impurity 82 (CAS 1306528-12-0)
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- 5-Fluoro-7-methyl-2,3-dihydro-1H-inden-1-one (CAS 1092347-80-2)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
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