Apixaban Impurity 50 CAS CATO-C4X-108850
| CAS No. | CATO-C4X-108850 |
| Molecular Formula | C19H15ClN4O3 |
| Molecular Weight | 382.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Apixaban Impurity 50 (CAS CATO-C4X-108850, C19H15ClN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H15ClN4O3, Apixaban Impurity 50 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 382.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H15ClN4O3 |
| Molecular Weight | 382.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Apixaban Standards
- Apixaban Impurity 52 (CAS CATO-C4X-108852)
- Apixaban Impurity 127 (CAS CATO-C4X-1088127)
- Apixaban Impurity 42 (CAS 1704504-93-7)
- Apixaban Impurity 12 (CAS 1423803-24-0)
- Apixaban Impurity 103 (CAS CATO-C4X-1088103)
- Apixaban Impurity 145 (CAS CATO-C4X-1088145)
- Apixaban Impurity 83 (CAS CATO-C4X-108883)
- Apixaban Impurity 26 (CAS 1643330-62-4)
Recommended Standards
- N-(benzo[d][1,3]dioxol-5-yl)-1-(2-chlorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 400077-83-0)
- 2-Bromo-4,5-dichloro-6-iodo-3-methoxypyridine (CAS 1305324-56-4)
- N-(2H-1,3-Benzodioxol-5-yl)-2-(4-chloro-2-methylphenoxy)pyridine-3-carboxamide (CAS 497060-31-8)
- (3-(Azepan-1-yl)-5-(trifluoromethyl)pyridin-2-yl)(4-chlorophenyl)methanone (CAS 338959-89-0)
- Bilastine impurity 97 (CAS CATO-C4X-225397)
- Levocabastine EP Impurity L (CAS CATO-C4X-228912)
- Trazodone Impurity 102 (CAS CATO-C4X-1772102)
- 3-Methylisoxazolo[5,4-b]pyridine-4,6-diol (CAS 63523-55-7)
- (S)-2-amino-3-(5-fluoropyridin-2-yl)propanoic acid (CAS 1270264-67-9)
- (4-((2,4-Dichlorobenzyl)oxy)phenyl)boronic acid (CAS 1256355-75-5)
- 4-(Chlorosulfonyl)thiophene-2-carboxylic acid (CAS 79279-54-2)
- Terbutaline Impurity 60 (CAS 35086-59-0)
- 7-Isocyanato-2,2-dimethyl-2,3-dihydrobenzofuran (CAS 87254-55-5)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
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