Rivaroxaban impurity 167 CAS CATO-C4X-1090167
| CAS No. | CATO-C4X-1090167 |
| Molecular Formula | C21H20N4O6 |
| Molecular Weight | 424.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Rivaroxaban impurity 167 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Rivaroxaban impurity 167 (CAS CATO-C4X-1090167) is a certified pharmaceutical impurity reference standard with the molecular formula C21H20N4O6 and a molecular weight of 424.41 g/mol.
Rivaroxaban impurity 167 (C21H20N4O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H20N4O6 |
| Molecular Weight | 424.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 160 (CAS CATO-C4X-1090160)
- Rivaroxaban Impurity 177 (CAS CATO-C4X-1090177)
- Rivaroxaban Impurity 183 (CAS CATO-C4X-1090183)
- Rivaroxaban Impurity 186 (CAS CATO-C4X-1090186)
- Rivaroxaban Impurity 100 (CAS CATO-C4X-1090100)
- Rivaroxaban Impurity 104（Enantiomer Mixture） (CAS 1265617-06-8)
- Rivaroxaban Impurity 31 (CAS 1424944-35-3)
- Rivaroxaban EP Impurity G (CAS 446292-08-6)
Recommended Standards
- Ethyl 2-((4-fluorobenzyl)(4-(trifluoromethyl)phenyl)amino)thiazole-4-carboxylate (CAS 860783-96-6)
- 3-{[(4-chlorophenyl)methyl]sulfanyl}-5-({[(4-chlorophenyl)methyl]sulfanyl}methyl)-4-ethyl-4H-1,2,4-triazole (CAS 344268-69-5)
- 3,3'-Dihydroxy-1H,1'H-[2,2'-biindole]-5,5'-disulfonic acid (CAS 28286-71-7)
- Rilpivirine impurity 10 (CAS CATO-C4X-136310)
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- Indapamide Impurity 33 (CAS 22160-13-0)
- Alanyl Glutamine Impurity 24 TFA Salt (CAS CATO-C4X-197424)
- Vonoprazan Fumarate Impurity 27 (CAS CATO-C4X-102027)
- 4-Chloro-2-methyl-2,3-dihydro-1H-inden-1-one (CAS 245653-50-3)
- 3-Chloro-6-(trimethylstannyl)isoquinoline (CAS 1380613-06-8)
- Niraparib Impurity 68 (CAS CATO-C4X-232968)
- Avibactam Impurity 124 (CAS CATO-C4X-1348124)
- 4-(6-Nitroindazol-1-yl)-1,1-dioxo-thiolan-3-ol (CAS 1179857-56-7)
- (Des-His1,Glu?)-Glucagon (1-29) amide (human, rat, porcine) (CAS 110084-95-2)
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