Azilsartan Impurity 49 CAS CATO-C4X-109649
| CAS No. | CATO-C4X-109649 |
| Molecular Formula | C53H38N8O12 |
| Molecular Weight | 978.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Azilsartan Impurity 49 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Azilsartan Impurity 49 (CAS CATO-C4X-109649) is a certified pharmaceutical impurity reference standard with the molecular formula C53H38N8O12 and a molecular weight of 978.92 g/mol.
Azilsartan Impurity 49 (C53H38N8O12) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C53H38N8O12 |
| Molecular Weight | 978.92 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 39.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
Related Azilsartan Standards
- Azilsartan Impurity 88 (CAS CATO-C4X-109688)
- Azilsartan Impurity 48 (CAS CATO-C4X-109648)
- Azilsartan Impurity 50 (CAS 1417576-02-3)
- Azilsartan Impurity 154 (CAS 1675221-57-4)
- Azilsartan (CAS 1675221-56-3)
- Azilsartan Impurity 152 (CAS 1675270-44-6)
- Azilsartan Impurity 86 (CAS 2117636-55-0)
- Azilsartan Impurity 151 (CAS 1454318-14-9)
Recommended Standards
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- Olmesartan Impurity 87 (CAS CATO-C4X-109787)
- N4-methylcytidine Phosphoramidite (CAS CATO-C4X-288612)
- Cefprozil impurity 66 (CAS 132313-55-4)
- Amorolfine EP Impurity G HCl (CAS 1260498-35-8)
- Peramivir Impurity 12 (CAS 19503-26-5)
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- N-(4-(4-Ethoxyphenyl)thiazol-2-yl)pivalamide (CAS 433967-45-4)
- 3-Iodo-8-methoxy-2-(trifluoromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 2648773-69-5)
- 6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-chloro-3-nitrobenzoate (CAS 877636-58-3)
- (2,4-Dichlorophenyl)(5-(5-((4-fluorophenoxy)methyl)-1,3,4-oxadiazol-2-yl)-1-methyl-1H-pyrrol-3-yl)methanone (CAS 338418-73-8)
- tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylate (CAS 178311-48-3)
- Smac-N7 Peptide (CAS 401913-57-3)
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