Ezetimibe Impurity 64 CAS CATO-C4X-109864
| CAS No. | CATO-C4X-109864 |
| Molecular Formula | C27H29F2NO3Si |
| Molecular Weight | 481.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ezetimibe Impurity 64 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ezetimibe Impurity 64 (CAS CATO-C4X-109864) is a certified pharmaceutical impurity reference standard with the molecular formula C27H29F2NO3Si and a molecular weight of 481.61 g/mol.
Ezetimibe Impurity 64 (C27H29F2NO3Si) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H29F2NO3Si |
| Molecular Weight | 481.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 65 (CAS CATO-C4X-109865)
- Ezetimibe Impurity 57 (CAS CATO-C4X-109857)
- Ezetimibe Impurity C115 (CAS 204589-96-8)
- Ezetimibe Impurity 6 (CAS CATO-C4X-10986)
- Ezetimibe Impurity 7 (CAS CATO-C4X-10987)
- Ezetimibe diacetate (CAS 163380-20-9)
- Ezetimibe Impurity 12(Intermediate Isomer Impurity) (CAS CATO-C4X-109812)
- Ezetimibe Impurity 8 (CAS CATO-C4X-10988)
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