Ezetimibe Impurity 84 CAS CATO-C4X-109884
| CAS No. | CATO-C4X-109884 |
| Molecular Formula | C36H38F2N2O5Si |
| Molecular Weight | 644.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ezetimibe Impurity 84.
Ezetimibe Impurity 84 (CAS CATO-C4X-109884) is a certified pharmaceutical impurity reference standard with the molecular formula C36H38F2N2O5Si and a molecular weight of 644.78 g/mol.
Structurally, Ezetimibe Impurity 84 (C36H38F2N2O5Si) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 644.78 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C36H38F2N2O5Si |
| Molecular Weight | 644.78 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Ezetimibe Standards
- Ezetimibe Impurity 85 (CAS CATO-C4X-109885)
- Ezetimibe Impurity 77 (CAS CATO-C4X-109877)
- Ezetimibe Phenoxy tert-Butyldiphenylsilyl Ether (CAS 1042722-66-6)
- Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether (CAS 1217748-67-8)
- Ezetimibe Impurity 48 (CAS 1185883-39-9)
- Ezetimibe Impurity 89 (CAS CATO-C4X-109889)
- Ezetimibe Impurity 141 (CAS CATO-C4X-1098141)
- Ezetimibe Impurity 143 (CAS CATO-C4X-1098143)
Recommended Standards
- Hoveyda-Grubbs Catalyst 2nd Generation 301224-40-8 (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM;(1,3-DIMESITYLIMIDAZOLIDIN-2-YLIDENE)(2-ISOPROPOXYBENZYLIDENE)RUTHENIUM(VI) CHLORIDE;HOVEYDA-GRUBBS 2ND GENERATION;HOVEYDA-GRUBBS CATALYST 2ND GENERATION;RUTHENIUM,[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO[[2-(1-METHYLETHOXY)PHENYL]METHYLENE];[1,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO(2-ISOPROPOXYPHENYLMETHYLENE)RUTHENIUM SC10095 (CAS 301224-40-8)
- 4,4'-(15,20-Diphenyl-21H,23H-porphine-5,10-diyl)bis[benzenamine] (CAS 116206-76-9)
- Boc-NH-PEG11-NH2 (CAS 1233234-77-9)
- 5,15-Di(4-aminophenyl)-10,20-diphenyl porphine (CAS 116206-75-8)
- Voriconazole Impurity 33 (CAS 1449785-88-9)
- Posaconazole Impurity 111 (CAS 112559-81-6)
- Avibactam Impurity 12 (CAS 1383814-64-9)
- Sulfinpyrazone (CAS 57-96-5)
- 5-(1-(3-Chlorophenyl)-5-methyl-1H-pyrazol-4-yl)-4H-1,2,4-triazole-3-thiol (CAS 1019090-30-2)
- (E)-1-(1,5-Dimethyl-1h-pyrazol-4-yl)-3-(dimethylamino)prop-2-en-1-one (CAS 1001500-19-1)
- 1-[(4-Chlorophenyl)methyl]-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile (CAS 339108-97-3)
- Praziquantel Impurity 5 (CAS 79848-92-3)
- 3',5'-Dimethyl-[1,1'-biphenyl]-3-carbaldehyde (CAS 842140-47-0)
- Galanin Message Associated Peptide (44-59) amide (CAS 125455-59-6)
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