Ezetimibe Impurity 77 CAS CATO-C4X-109877
| CAS No. | CATO-C4X-109877 |
| Molecular Formula | C36H36F2N2O5Si |
| Molecular Weight | 642.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ezetimibe Impurity 77 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ezetimibe Impurity 77 (CAS CATO-C4X-109877, C36H36F2N2O5Si) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ezetimibe Impurity 77 (C36H36F2N2O5Si) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ezetimibe Impurity 77 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C36H36F2N2O5Si |
| Molecular Weight | 642.76 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Ezetimibe Standards
- Ezetimibe Impurity 84 (CAS CATO-C4X-109884)
- Ezetimibe Impurity 85 (CAS CATO-C4X-109885)
- Ezetimibe Phenoxy tert-Butyldiphenylsilyl Ether (CAS 1042722-66-6)
- Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether (CAS 1217748-67-8)
- Ezetimibe Impurity 48 (CAS 1185883-39-9)
- Ezetimibe Impurity 89 (CAS CATO-C4X-109889)
- Ezetimibe Impurity 141 (CAS CATO-C4X-1098141)
- Ezetimibe Impurity 143 (CAS CATO-C4X-1098143)
Recommended Standards
- 3,3'-((2,5-Dimethylpiperazine-1,4-diyl)bis(methylene))bis(5,5-diphenylimidazolidine-2,4-dione) (CAS 5545-94-8)
- Ritonavir Impurity 46 (CAS 1010809-54-7)
- Steviolbioside (CAS 41093-60-1)
- H-Arg-Arg-Arg-Arg-OH (CAS 26791-46-8)
- Fenfluramine Impurity 1 (CAS 19023-40-6)
- Iguratimod Impurity 109 (CAS CATO-C4X-1826109)
- Fluconazole Impurity 43 (CAS 41253-21-8)
- 2,4-Dimethyl-7H-chromen-7-one (CAS 465537-87-5)
- 2-(5-Methyl-1,2,4-oxadiazol-3-yl)morpholine hydrochloride (CAS 1443979-69-8)
- N-methyl-4-(pyrazin-2-yl)thiazol-2-amine (CAS 91516-46-0)
- CAS 287111-42-6 (CAS 287111-42-6)
- 6-(Dimethylphosphoryl)nicotinaldehyde (CAS 2624118-98-3)
- 1-bromo-3,3-dimethylpentane (CAS 6188-50-7)
- Des-Ser32-Tirzepatide (CAS CATO-CPTD788942)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com