Alogliptin Impurity 12 HCl CAS CATO-C4X-109912
| CAS No. | CATO-C4X-109912 |
| Molecular Formula | C26H26N6O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Alogliptin Impurity 12 HCl is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Alogliptin Impurity 12 HCl (CAS CATO-C4X-109912) is a certified pharmaceutical impurity reference standard with the molecular formula C26H26N6O2HCl and a molecular weight of 490.99 g/mol.
Structurally, Alogliptin Impurity 12 HCl (C26H26N6O2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 490.99 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Alogliptin Impurity 12 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H26N6O2 HCl |
| Molecular Weight | 490.99 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Alogliptin Standards
- Alogliptin Impurity 3 (CAS 1108731-49-2)
- Alogliptin Impurity 89 (CAS 1108732-05-3)
- Alogliptin impurity 77 HCl (CAS 1108732-05-3（free base）)
- Alogliptin Impurity 51 (CAS 1133421-35-8)
- Alogliptin Impurity 38 (CAS 120977-94-8)
- Alogliptin Impurity 16 (CAS 1217476-03-3)
- Alogliptin Impurity 33 (CAS 123-56-8)
- Alogliptin Impurity 69 (CAS 1243378-31-5)
Recommended Standards
- Ceftazidime Impurity 73 (CAS CATO-C4X-121273)
- Lacidipine BP Impurity B (CAS 130996-24-6)
- Bilastine Impurity 12 (CAS 2099128-83-1)
- 2'-Deoxyadenosine monohydrate (CAS 16373-93-6)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
- 4-(Benzyloxy)-2-methoxy-6-chloropyridine (CAS 1934854-20-2)
- 5-Bromo-2-fuoro-3-methylphenol (CAS 1351668-25-1)
- 4,5,6-Triethoxy-7-nitro-3h-isobenzofuran-1-one (CAS 4995-54-4)
- (2-(1,3,5-Trimethyl-1H-pyrazol-4-yl)quinolin-4-yl)methanol (CAS 1354706-40-3)
- Proinsulin C-Peptide (55-89) (human) (CAS 11097-48-6)
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