Linagliptin impurity 153 CAS CATO-C4X-1101153
| CAS No. | CATO-C4X-1101153 |
| Molecular Formula | C51H56N16O4 |
| Molecular Weight | 957.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Linagliptin impurity 153 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Linagliptin impurity 153 (CAS CATO-C4X-1101153, C51H56N16O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Linagliptin impurity 153 (C51H56N16O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C51H56N16O4 |
| Molecular Weight | 957.10 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 32.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 16 |
Related Linagliptin Standards
- Linagliptin Methyl Dimer (CAS 2463617-49-2)
- Linagliptin Impurity 88 (CAS 2489212-72-6)
- Linagliptin impurity 127 (CAS 1418133-47-7)
- Linagliptin impurity 166 (CAS CATO-C4X-1101166)
- Linagliptin impurity 19 (CAS CATO-C4X-110119)
- Linagliptin Impurity 82 (CAS CATO-C4X-110182)
- Linagliptin Impurity 76 (Mixture of Diastereomers) (CAS CATO-C4X-110176)
- Linagliptin Impurity 104 (CAS CATO-C4X-1101104)
Recommended Standards
- (11bR)-4-Hydroxy-2,6-bis(5'-phenyl-[1,1':3',1''-terphenyl]-4'-yl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide (CAS 2640982-29-0)
- Oxyntomodulin (30-37) (bovine, dog, porcine) (CAS 81117-26-2)
- (11bS)-4-hydroxy-2,6-bis(5'-phenyl-[1,1':3',1''-terphenyl]-4'-yl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide (CAS 1639447-03-2)
- Soyasaponin Bd (CAS 135272-91-2)
- Trenbolone Impurity 2 (CAS 53303-85-8)
- Ketorolac Impurity 43 (CAS CATO-C4X-166943)
- Bacitracin Impurity Q (CAS CATO-C4X-155317)
- Triethoxysilylundecanal (CAS 116047-42-8)
- Tert-butyl ((1s,3s)-3-cyano-3-fluorocyclobutyl)carbamate (CAS 2250243-47-9)
- 4-Bromo-6-chloro-2-methylbenzimidazole (CAS 1215205-57-4)
- Ataciguat (CAS 254877-67-3)
- Thalidomide-O-PEG4-amine (CAS 2401832-00-4)
- tert-butyl 3-(bromomethyl)-3-methylazetidine-1-carboxylate (CAS 1408075-52-4)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
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