Linagliptin impurity 152 CAS CATO-C4X-1101152
| CAS No. | CATO-C4X-1101152 |
| Molecular Formula | C20H19N7O2 |
| Molecular Weight | 389.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Linagliptin impurity 152 (CAS CATO-C4X-1101152) is a certified pharmaceutical impurity reference standard with the molecular formula C20H19N7O2 and a molecular weight of 389.41 g/mol.
Structurally, Linagliptin impurity 152 (C20H19N7O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 389.41 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H19N7O2 |
| Molecular Weight | 389.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Linagliptin Standards
- Linagliptin Impurity 58 (CAS CATO-C4X-110158)
- Linagliptin impurity 116 (CAS CATO-C4X-1101116)
- Linagliptin impurity 125 (CAS CATO-C4X-1101125)
- Linagliptin Impurity 49 (CAS CATO-C4X-110149)
- Linagliptin impurity 140 (CAS 2428491-17-0)
- Linagliptin Impurity 4 (CAS 2749405-42-1)
- Linagliptin impurity 118 (CAS CATO-C4X-1101118)
- Linagliptin Impurity 47 (CAS 2468656-63-3)
Recommended Standards
- Ibrutinib Impurity 174 (CAS CATO-C4X-1064174)
- Sitagliptin Impurity 86 (CAS 1246961-45-4)
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- Nafamostat impurity 110 (CAS 107490-62-0)
- Nintedanib Impurity 48 DiHCl (CAS 5395-70-0)
- Azilsartan Impurity 65 (CAS CATO-C4X-109665)
- Dexrazoxane Impurity 1 2H2SO4 (CAS CATO-C4X-20201)
- 2-Amino-4-methylbenzoyl chloride (CAS 1261522-23-9)
- 5,8-Dichloronaphthalen-1-amine (CAS 3604-99-7)
- Ethyltris(dimethylsiloxy)silane (CAS 150320-87-9)
- 7-Bromo-2-(4-hydroxy-2-methylphenyl)benzo[d]oxazol-5-ol (CAS 440122-81-6)
- 3’-Bromo-2’-methylacetophenone (CAS 52779-76-7)
- Allyl-2-d (CAS 60468-26-0)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
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