Gefitinib Impurity 81 CAS CATO-C4X-111781
| CAS No. | CATO-C4X-111781 |
| Molecular Formula | C21H18O5 |
| Molecular Weight | 350.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Gefitinib Impurity 81 (C21H18O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Gefitinib Impurity 81 (CAS CATO-C4X-111781) is a certified pharmaceutical impurity reference standard with the molecular formula C21H18O5 and a molecular weight of 350.36 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Gefitinib Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H18O5 |
| Molecular Weight | 350.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Gefitinib Standards
- Gefitinib Impurity 61 (CAS 950596-57-3)
- Gefitinib Impurity 59 (CAS CATO-C4X-111759)
- Gefitinib Impurity 29 (CAS 861453-16-9)
- Gefitinib Impurity 51 (CAS CATO-C4X-111751)
- Gefitinib Impurity 53 (CAS CATO-C4X-111753)
- Gefitinib Impurity 6 (CAS 788136-89-0)
- Gefitinib Impurity 16 (CAS CATO-C4X-111716)
- Gefitinib Impurity 50 (CAS 199327-59-8)
Recommended Standards
- 2,7-Dimethyl-1,4-dihydroxynaphthalene 1-O-glucoside 839711-70-5 (CAS 839711-70-5)
- Spectinomycin EP Impurity D (CAS 935756-69-7)
- Spectinomycin Impurity 1 (CAS 3736-78-5)
- Spectinomycin EP Impurity B (CAS CATO-C4X-22166)
- Milrinone Impurity 28 (CAS CATO-C4X-109128)
- Safinamide Impurity 19 (CAS 70627-20-2)
- Thiamine Impurity 30 (CAS 100502-51-0)
- 3-(1-Isopropylpiperidin-2-yl)-N,N-dimethylpyridin-2-amine (CAS 1352506-05-8)
- Dydrogesterone Impurity 15 (CAS 32164-74-2)
- 2-(1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3,5-dimethyl-1H-pyrazol-4-yl)acetic acid (CAS 1416341-43-9)
- 2-(Thiophen-2-yl)piperidine (CAS 270902-38-0)
- Fezolinetant Impurity 10 (CAS CATO-C4X-327010)
- GW779439X (CAS 551919-98-3)
- Semaglutide impurity 200 (CAS CATO-C4X-2226200)
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