Gefitinib Impurity 29 CAS 861453-16-9
| CAS No. | 861453-16-9 |
| Molecular Formula | C15H21N3O6 |
| Molecular Weight | 339.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Gefitinib Impurity 29.
Gefitinib Impurity 29 (CAS 861453-16-9) is a certified pharmaceutical impurity reference standard with the molecular formula C15H21N3O6 and a molecular weight of 339.34 g/mol.
The molecular framework of Gefitinib Impurity 29 (C15H21N3O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H21N3O6 |
| Molecular Weight | 339.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 3 |
Related Gefitinib Standards
- Gefitinib Impurity 50 (CAS 199327-59-8)
- Gefitinib Impurity 75 (CAS CATO-C4X-111775)
- Gefitinib Impurity 19 (CAS 153437-78-6)
- Gefitinib Impurity 20 (CAS 690206-97-4)
- Gefitinib impurity 66 (CAS CATO-C4X-111766)
- Gefitinib Impurity 94 (CAS CATO-C4X-111794)
- Gefitinib Impurity 59 (CAS CATO-C4X-111759)
- Gefitinib Impurity 24 (CAS CATO-C4X-111724)
Recommended Standards
- Dronedarone Impurity 85 (CAS CATO-C4X-109285)
- Piracetam impurity 35 (CAS CATO-C4X-123535)
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- Neomycin Impurity 18 (CAS CATO-C4X-184518)
- Dexamethasone Impurity 19 (CAS CATO-C4X-116519)
- Verapamil EP Impurity N HCl (CAS 2086274-75-9 (free base))
- Agomelatine Diacetyl Impurity (CAS 1379005-34-1)
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- 3-((4-Fluorophenyl)sulfonyl)-N-(2-(phenylsulfonyl)ethyl)propanamide (CAS 337923-49-6)
- 2,4-Dichloro-5-methoxybenzoic acid (CAS 71685-44-4)
- 2,8-Dimethyl-5-methyleneimidazo[1,2-a]pyrazine-3,6(5H,7H)-dione (CAS 207000-31-5)
- tert-Butyl 4-(4-bromobutyl)piperidine-1-carboxylate (CAS 142355-81-5)
- Tau Peptide (307-321) trifluoroacetate salt (CAS 330456-50-3)
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