Avanafil Impurity 136 CAS CATO-C4X-1118136
| CAS No. | CATO-C4X-1118136 |
| Molecular Formula | C16H17ClN4O5S |
| Molecular Weight | 412.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Avanafil Impurity 136 (CAS CATO-C4X-1118136, C16H17ClN4O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Avanafil Impurity 136 (C16H17ClN4O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Avanafil Impurity 136 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H17ClN4O5S |
| Molecular Weight | 412.85 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Avanafil Standards
- Avanafil Impurity 124 (CAS CATO-C4X-1118124)
- Avanafil Impurity 41 (CAS CATO-C4X-111841)
- Avanafil Impurity 50 (CAS CATO-C4X-111850)
- Avanafil Impurity 62 (CAS CATO-C4X-111862)
- Avanafil Impurity 8 (CAS CATO-C4X-11188)
- Avanafil Impurity 84 (CAS CATO-C4X-111884)
- Avanafil Impurity 9 (CAS CATO-C4X-11189)
- Avanafil Impurity 40 (CAS CATO-C4X-1118140)
Recommended Standards
- (E)-{[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylidene}[(4-nitrophenyl)methoxy]amine (CAS 338404-56-1)
- (3,4-Bis((trimethylsilyl)ethynyl)hexa-3-en-1,5-diyne-1,6-diyl)bis(trimethylsilane) (CAS 55660-76-9)
- 4-Oxo-2-phenylquinazolin-3(4H)-yl 4-chlorobenzenesulfonate (CAS 130536-25-3)
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-1-[4-(trifluoromethyl)benzoyl]-1,4,5,6-tetrahydropyrimidine (CAS 866153-37-9)
- Guaiazulene Impurity 4 (CAS CATO-C4X-22374)
- Articaine EP Impurity F HCl (CAS CATO-C4X-19127)
- CAS 2658608-80-9 (CAS 2658608-80-9)
- 3-Bromo-5-cyano-4-formylbenzoic acid (CAS 1806062-24-7)
- 1-(4-fluorophenyl)-2-(oxolan-3-yl)ethan-1-one (CAS 1564663-22-4)
- 4H-Pyrazolo[1,5-a]pyrimidin-5-one sodium salt (CAS 1224944-43-7)
- 2-Heptanone,5-(Hydroxymethyl) (CAS 498572-74-0)
- tert-Butyl (4-(aminomethyl)bicyclo[2.2.1]heptan-1-yl)carbamate (CAS 1333384-66-9)
- (E)-N-(2,5-dichlorophenyl)-3-(furan-2-yl)acrylamide (CAS 424814-07-3)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com