Avanafil Impurity 41 CAS CATO-C4X-111841
| CAS No. | CATO-C4X-111841 |
| Molecular Formula | C18H19ClN4O5 |
| Molecular Weight | 406.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Avanafil Impurity 41 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Avanafil Impurity 41 (CAS CATO-C4X-111841, C18H19ClN4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Avanafil Impurity 41 (C18H19ClN4O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 406.82 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19ClN4O5 |
| Molecular Weight | 406.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Avanafil Standards
- Avanafil Impurity 50 (CAS CATO-C4X-111850)
- Avanafil Impurity 124 (CAS CATO-C4X-1118124)
- Avanafil Impurity 8 (CAS CATO-C4X-11188)
- Avanafil Impurity 115 (CAS CATO-C4X-1118115)
- Avanafil Impurity 117 (CAS CATO-C4X-1118117)
- Avanafil Impurity 121 (CAS CATO-C4X-1118121)
- Avanafil Impurity 134 (CAS CATO-C4X-1118134)
- Avanafil Impurity 22 (CAS 2250242-48-7)
Recommended Standards
- N-(5-chloropyridin-2-yl)-2-(4-cyanobenzamido)-5-methoxybenzamide (CAS 330942-01-3)
- N-(3-Chloro-2-methylphenyl)-3-(4-fluoro-2-nitrophenoxy)thiophene-2-carboxamide (CAS 306977-59-3)
- 1-(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethyl)-3-[(1E)-(dimethylamino)methylidene]urea (CAS 338792-96-4)
- N-(3-chloro-2-methylphenyl)-3-(2-fluoro-4-nitrophenoxy)thiophene-2-carboxamide (CAS 303152-56-9)
- Ilaprazole Impurity 70 (CAS 2285346-40-7)
- Dacomitinib Impurity 16 (CAS CATO-C4X-208616)
- Atrasentan Impurity 14 (CAS 1140617-05-5)
- 3-Chloro-N-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)benzamide (CAS 477885-68-0)
- N-(3-Ethoxy-4-methoxybenzyl)cyclopentanamine hydrobromide (CAS 1609400-11-4)
- Ethyl 6-(4-benzylpiperazin-1-yl)picolinate (CAS 1353878-17-7)
- Ataluren Impurity 15 (CAS CATO-C4X-300615)
- Trandolapril Related Compound 5 HCl (CAS 145513-93-5 (free base))
- Hg in water quality (CAS CATO-CQCM102200)
- D-[Ser]8-Semaglutide (CAS CATO-CPTD788632)
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