Avanafil Impurity 153 CAS CATO-C4X-1118153
| CAS No. | CATO-C4X-1118153 |
| Molecular Formula | C24H33ClN6O3 |
| Molecular Weight | 489.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Avanafil Impurity 153 (CAS CATO-C4X-1118153, C24H33ClN6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Avanafil Impurity 153 (C24H33ClN6O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H33ClN6O3 |
| Molecular Weight | 489.01 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Avanafil Standards
- Avanafil Impurity 126 (CAS CATO-C4X-1118126)
- Avanafil-13C-d3 (CAS CATO-C4X-111836)
- Avanafil Impurity 96 (CAS 1643811-19-1)
- Avanafil Impurity 54 (CAS 1706458-94-7)
- Avanafil (CAS 330784-47-9)
- Avanafil Impurity 1 (CAS 1638497-26-3)
- Avanafil Impurity 107 (CAS CATO-C4X-1118107)
- Avanafil Impurity 35 (CAS CATO-C4X-111835)
Recommended Standards
- N,N'-(4,4'-methylenebis(4,1-phenylene))bis(2,2,2-trichloroacetamide) (CAS 550299-55-3)
- A-887826-d8 (CAS 1794753-88-0)
- N1,N3-diphenylpropane-1,3-diimine (CAS 5652-79-9)
- 3-(3,5-diiodo-4-hydroxyÂbenzÂoylÂ)-indole (CAS 138222-00-1)
- Carboprost Trometamol EP Impurity B (CAS 35864-81-4)
- Pimavanserin Impurity 22 (CAS CATO-C4X-193822)
- Simvastatin Impurity 18 (CAS CATO-C4X-119918)
- Bis(3,5-dimethyl-4-methoxyphenyl)chlorophosphine (CAS 136802-85-2)
- Diethyl (2,3-diphenylpyrido[3,4-b]pyrazine-5,7-diyl)dicarbamate (CAS 16335-96-9)
- Methyl 5-bromo-2-oxopentanoate (CAS 62691-70-7)
- Ethyl 2,3-difluoro-5-nitrophenylacetate (CAS 1803824-61-4)
- Ethyl 2-(((5-amino-1,3,4-thiadiazol-2-yl)thio)methyl)furan-3-carboxylate (CAS 923207-29-8)
- 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one 2,2,2-trifluoroacetate (CAS 1234064-11-9)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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