Atrasentan Impurity 14 CAS 1140617-05-5
| CAS No. | 1140617-05-5 |
| Molecular Formula | C25H30N2O6 |
| Molecular Weight | 454.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Atrasentan Impurity 14 (CAS 1140617-05-5, C25H30N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Atrasentan Impurity 14 (C25H30N2O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atrasentan Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H30N2O6 |
| Molecular Weight | 454.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 206 (CAS 1140617-21-5)
- Atrasentan Impurity 21 (CAS 1058392-86-1)
- Atrasentan Impurity 29 (CAS 1058392-69-0)
- Atrasentan Impurity 207 (CAS CATO-C4X-3347207)
- Atrasentan Impurity 17 (CAS 1140616-98-3)
- Atrasentan Impurity 22 (CAS 1058393-00-2)
- Atrasentan Impurity 34 (CAS 1058392-78-1)
- Atrasentan Impurity 35 (CAS 1058392-91-8)
Recommended Standards
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