Ivabradine impurity 63 CAS CATO-C4X-111963
| CAS No. | CATO-C4X-111963 |
| Molecular Formula | C12H16N2O3 |
| Molecular Weight | 236.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ivabradine impurity 63 (C12H16N2O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Ivabradine impurity 63 (CAS CATO-C4X-111963), a pharmacopoeial impurity reference standard (molecular formula C12H16N2O3, MW 236.27 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H16N2O3 |
| Molecular Weight | 236.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Ivabradine Standards
- Ivabradine Impurity 102 (CAS CATO-C4X-1119102)
- Ivabradine Impurity 44 (CAS 79623-31-7)
- Ivabradine Impurity 101 (CAS CATO-C4X-1119101)
- Ivabradine Impurity 25 (CAS 2512206-14-1)
- Ivabradine Impurity 65 (CAS 2387117-59-9)
- Ivabradine impurity 91 (CAS CATO-C4X-111991)
- Ivabradine Impurity 26 (CAS 20925-64-8)
- Ivabradine Impurity 100 (CAS CATO-C4X-1119100)
Recommended Standards
- Losartan Potassium EP Impurity E (CAS 120568-11-8)
- N-Nitroso Ivabradine impurity 85 (CAS CATO-C4X-111985)
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- Oxcarbazepine EP Impurity A (Carbamazepine) (CAS 298-46-4)
- Olmesartan Impurity 43 (CAS 1227664-85-8)
- Doxylamine EP Impurity C HCI (CAS 1221-70-1（free base）)
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