Losartan Potassium EP Impurity E CAS 120568-11-8
| CAS No. | 120568-11-8 |
| Molecular Formula | C14H12N4 |
| Molecular Weight | 236.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Losartan Potassium EP Impurity E is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Losartan Potassium EP Impurity E (CAS 120568-11-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H12N4 and a molecular weight of 236.27 g/mol.
The molecular framework of Losartan Potassium EP Impurity E (C14H12N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Losartan Potassium EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H12N4 |
| Molecular Weight | 236.27 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 4 |
Related Losartan Standards
- Losartan EP Impurity B (CAS 160514-13-6)
- Losartan Impurity 63 (CAS CATO-C4X-168363)
- Losartan Impurity 20 (CAS 154709-19-0)
- Losartan Impurity 42 (CAS 2901098-91-5)
- Losartan Impurity 43 (CAS 135689-84-8)
- Losartan Impurity 1 (CAS 79047-41-9)
- Losartan EP Impurity D (CAS 83857-96-9)
- Losartan Impurity 62 (CAS CATO-C4X-168362)
Recommended Standards
- Enzalutamide Impurity 68 (CAS CATO-C4X-101668)
- Ivabradine impurity 63 (CAS CATO-C4X-111963)
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- N-Nitroso Ivabradine impurity 85 (CAS CATO-C4X-111985)
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- Cloxacillin Impurity 42 (CAS CATO-C4X-232142)
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- 5-Chloro-1-(2,6-dichlorobenzyl)-N-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 339009-08-4)
- O-(1-(4-Methoxyphenyl)ethyl)hydroxylamine (CAS 1082600-75-6)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com