Ivabradine Impurity 81 CAS CATO-C4X-111981
| CAS No. | CATO-C4X-111981 |
| Molecular Formula | C11H15NO2 |
| Molecular Weight | 193.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ivabradine Impurity 81.
Ivabradine Impurity 81 (CAS CATO-C4X-111981) is a certified pharmaceutical impurity reference standard with the molecular formula C11H15NO2 and a molecular weight of 193.24 g/mol.
The molecular framework of Ivabradine Impurity 81 (C11H15NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H15NO2 |
| Molecular Weight | 193.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Ivabradine Standards
- Ivabradine Impurity 25 HCl (CAS 1132079-01-6)
- Ivabradine Impurity 16 (CAS 73344-75-9)
- Ivabradine Impurity 55 (CAS 35202-54-1)
- Ivabradine Impurity 76 (CAS 55171-70-5)
- Ivabradine Impurity 53 (CAS CATO-C4X-111953)
- Ivabradine Impurity 17 (CAS 866783-12-2)
- Ivabradine impurity 90 (CAS 1132667-04-9)
- Ivabradine impurity 86 (CAS 1220993-44-1)
Recommended Standards
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- Olmesartan Impurity 28 (CAS 114772-53-1)
- Carbamazepine EP Impurity B (CAS 611-64-3)
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- Dapagliflozin Impurity 170 (CAS CATO-C4X-1138170)
- Etoposide Impurity 40 (CAS CATO-C4X-202440)
- Safinamide Impurity 34 (CAS CATO-C4X-159034)
- 8-((4-Bromophenyl)sulfonyl)-1,4-dioxa-8-azaspiro[4.5]Decane (CAS 849532-19-0)
- 5-Bromo-N-((4-phenyltetrahydro-2H-pyran-4-yl)methyl)furan-2-carboxamide (CAS 6107-26-2)
- Baricitinib Impurity 122 (CAS CATO-C4X-2260122)
- 1-(2-(Dimethylamino)-2-(pyridin-3-yl)ethyl)-3-(4-methoxyphenyl)thiourea (CAS 851946-11-7)
- 2-(5-Chlorochroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1154740-54-1)
- tert-Butyl 3-(methyl(pyrimidin-2-yl)amino)piperidine-1-carboxylate (CAS 1261231-84-8)
- Des-Ala35-Tirzepatide (CAS CATO-CPTD788939)
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