Canagliflozin Impurity 46 CAS CATO-C4X-112346
| CAS No. | CATO-C4X-112346 |
| Molecular Formula | C18H12BrFOS |
| Molecular Weight | 375.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Canagliflozin Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Canagliflozin Impurity 46 (CAS CATO-C4X-112346), a pharmacopoeial impurity reference standard (molecular formula C18H12BrFOS, MW 375.25 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Canagliflozin Impurity 46 (C18H12BrFOS) is characterized by a steroid core, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H12BrFOS |
| Molecular Weight | 375.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Sulfur Atoms | 1 |
Related Canagliflozin Standards
- Canagliflozin impurity 117 (CAS 1818268-44-8)
- Canagliflozin Impurity 97 (CAS CATO-C4X-112397)
- Canagliflozin Impurity 95 (CAS 10388-25-7)
- Canagliflozin Impurity 40 (CAS 1030825-20-7)
- Canagliflozin impurity 9 (CAS 2444540-01-4)
- Canagliflozin Impurity 84 (CAS CATO-C4X-112384)
- Canagliflozin Impurity 113 (CAS 2639148-37-9)
- Canagliflozin Impurity 92 (CAS CATO-C4X-112392)
Recommended Standards
- Pentafluorophenyl 2-morpholin-4-ylpyrimidine-5-carboxylate (CAS 941717-05-1)
- 2,4-bis(chlorosulfonyl)phenyl pivalate (CAS CATO-C4X-212340)
- N-(2,4-dichlorophenyl)-3-(dimethylamino)-4-phenyl-1H-pyrazole-1-carboxamide (CAS 321538-51-6)
- 2-NP-DNSAH (CAS 851368-01-9)
- Cefamandole EP Impurity A(Triethylamine Salt) (CAS 1947364-12-6)
- Propranolol Impurity 56 (CAS CATO-C4X-151956)
- Butylphthalide Impurity 15 (CAS 3453-64-3)
- Methyl 2-bromo-2-(4-iodophenyl)acetate (CAS 63349-67-7)
- (R)-1-(5-Fluoropyridin-3-yl)ethanamine hydrochloride (CAS 1956435-73-6)
- 3-Butoxy-5-fluoro-4-methylbenzoic acid (CAS 1429903-47-8)
- (4-((Trifluoromethyl)thio)phenyl)hydrazine (CAS 88575-32-0)
- Dibenzo[b,d]thiophen-1-ylboronic acid (CAS 1245943-60-5)
- 2-(tert-Butyl)-5-hydroxy-N-methylbenzamide (CAS 1243365-32-3)
- Semaglutide impurity 29 (CAS 110990-08-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com