AZD-9291 Impurity 5 CAS CATO-C4X-11275
| CAS No. | CATO-C4X-11275 |
| Molecular Formula | C24H27N7O3 |
| Molecular Weight | 461.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, AZD-9291 Impurity 5 (CAS CATO-C4X-11275, C24H27N7O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of AZD-9291 Impurity 5 (C24H27N7O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H27N7O3 |
| Molecular Weight | 461.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Recommended Standards
- Palbociclib impurity 163 (CAS CATO-C4X-1125163)
- Osimertinib impurity 52 (CAS 2408329-87-1)
- Palbociclib Impurity 127 (CAS CATO-C4X-1125127)
- Osimertinib Impurity 82 (CAS CATO-C4X-204582)
- Piracetam Impurity 50 (CAS CATO-C4X-123550)
- Brivaracetam Impurity 87 (CAS 1956436-60-4)
- Fluticasone Impurity 107 (CAS CATO-C4X-1650107)
- 6-Chloro-2-propyl-1H-benzo[d]imidazole-5-sulfonamide (CAS 89725-06-4)
- 5-Hydroxypiperidine-3-carboxylic Acid Hydrochloride (CAS 1171511-34-4)
- (3,4-Dimethylphenyl)hydrazine xhydrochloride (CAS 86746-50-1)
- Sofosbuvir Impurity 95 (CAS CATO-C4X-105295)
- (3-Cyanopyrazin-2-yl)boronic acid (CAS 1234213-84-3)
- 2-Cyclopropoxy-N1,N3-dimethylisophthalamide (CAS 1243348-22-2)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com