Dapagliflozin Impurity 138 CAS CATO-C4X-1138138
| CAS No. | CATO-C4X-1138138 |
| Molecular Formula | C24H31ClO8 |
| Molecular Weight | 482.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 138 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dapagliflozin Impurity 138 (CAS CATO-C4X-1138138) is a certified pharmaceutical impurity reference standard with the molecular formula C24H31ClO8 and a molecular weight of 482.95 g/mol.
Structurally, Dapagliflozin Impurity 138 (C24H31ClO8) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 482.95 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dapagliflozin Impurity 138 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H31ClO8 |
| Molecular Weight | 482.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 83 (CAS CATO-C4X-113883)
- Dapagliflozin Impurity 81 (CAS CATO-C4X-113881)
- Dapagliflozin Impurity 24 (CAS 2176485-21-3)
- Dapagliflozin Impurity 131 (CAS CATO-C4X-1138131)
- Dapagliflozin Impurity 72 (CAS CATO-C4X-113872)
- Dapagliflozin Impurity 84 (CAS CATO-C4X-113884)
- Dapagliflozin Impurity 48 (CAS CATO-C4X-113848)
- Dapagliflozin Impurity 152 (CAS 32384-64-8)
Recommended Standards
- Amlodipine Impurity 141 (CAS CATO-C4X-1095141)
- 2,8-Dibromo-5,5-difluoro-1,3,7,9-tetramethyl-10-(pyridin-4-yl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide (CAS 1600531-44-9)
- Amlodipine Impurity 139 (CAS CATO-C4X-1095139)
- 1-Butyl-2-[(E)-[(4-chloro-3-nitrophenyl)methylidene]amino]-4,5-diphenyl-1H-pyrrole-3-carbonitrile (CAS 478032-81-4)
- Clopidogrel Impurity 120 (CAS CATO-C4X-1029120)
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- 2-Ethynylnicotinonitrile (CAS 132898-81-8)
- 2-(3-Methoxypropyl)-2,3-dihydro-1h-isoindol-4-amine (CAS 1099644-34-4)
- (4-Bromo-2-(trifluoromethyl)phenyl)boronic acid (CAS 1394346-22-5)
- 4-Methylhexanenitrile (CAS 69248-32-4)
- Boc-D-Dap(Z)-OH · DCHA (CAS 81306-94-7)
- D-Leu26-Tirzepatide (CAS CATO-CPTD788908)
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