Dapagliflozin Impurity 52 CAS CATO-C4X-113852
| CAS No. | CATO-C4X-113852 |
| Molecular Formula | C27H31ClO9 |
| Molecular Weight | 534.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dapagliflozin Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dapagliflozin Impurity 52 (CAS CATO-C4X-113852, C27H31ClO9) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dapagliflozin Impurity 52 (C27H31ClO9) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C27H31ClO9 |
| Molecular Weight | 534.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin impurity 218 (CAS 3063007-40-6)
- Dapagliflozin Impurity N34 (CAS 1443341-94-3)
- Dapagliflozin Impurity 174 (CAS CATO-C4X-1138174)
- Dapagliflozin Impurity 107 (CAS CATO-C4X-1138107)
- Dapagliflozin Impurity 41 (CAS 1079083-63-8)
- Dapagliflozin Impurity 116 (CAS CATO-C4X-1138116)
- Dapagliflozin Impurity 190 (CAS CATO-C4X-1138190)
- Dapagliflozin Impurity 179 (CAS CATO-C4X-1138179)
Recommended Standards
- (3|A,15|A,17|A)-15,17-Bis-O-(tert-butyldimethylsilyloxy) Androst-5-en-3-ol (3|A,15|A,17|A)-15,17-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]androst-5-en-3-ol 65429-25-6 (CAS 65429-25-6)
- 3-(3-(2-(4-(3-Carbamimidoylphenoxy)butoxy)phenyl)ureido)-4-chlorobenzene-1-sulfonyl fluoride (CAS 32919-84-9)
- Venetoclax Impurity 89 (CAS CATO-C4X-249589)
- Edoxaban impurity 132 (CAS CATO-C4X-1063132)
- Bromfenac Impurity 37 (CAS CATO-C4X-200237)
- Lifitegrast Impurity 40 (CAS CATO-C4X-240940)
- Tenofovir Alafenamide Impurity 37 (CAS CATO-C4X-179737)
- 1-[2-(Dimethylamino)ethyl]-5-oxopyrrolidine-3-carboxamide (CAS 1219827-73-2)
- Ethyl 1-(3-fluoro-2-nitrophenyl)piperidine-4-carboxylate (CAS 733749-63-8)
- 5-(6-Ethoxy-2,3-difluorophenyl)oxazole (CAS 2379321-90-9)
- 4-Bromo-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-fluorobenzamide (CAS 930485-68-0)
- 5-(Thiophen-2-yl)oxazole-4-carboxylic acid (CAS 143659-15-8)
- 1-(2-(Methoxycarbonyl)-4-nitrophenyl)azetidine-3-carboxylic acid (CAS 1234873-83-6)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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