Lenvatinib Impurity 65 CAS CATO-C4X-114065
| CAS No. | CATO-C4X-114065 |
| Molecular Formula | C21H21ClN4O4 |
| Molecular Weight | 428.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Lenvatinib Impurity 65 (CAS CATO-C4X-114065, C21H21ClN4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lenvatinib Impurity 65 (C21H21ClN4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lenvatinib Impurity 65 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H21ClN4O4 |
| Molecular Weight | 428.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 85 (CAS CATO-C4X-114085)
- Lenvatinib Impurity 118 (CAS CATO-C4X-1140118)
- Lenvatinib Impurity 120 (CAS CATO-C4X-1140120)
- Lenvatinib Impurity 29 (CAS 417717-21-6)
- Lenvatinib-d4 (CAS 2264050-65-7)
- Lenvatinib Impurity 113 (CAS CATO-C4X-1140113)
- Lenvatinib Impurity 2 (CAS CATO-C4X-11402)
- Lenvatinib-d5 (CAS CATO-C4X-1140141)
Recommended Standards
- Methyl 2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetate (CAS 431979-47-4)
- Flomoxef Impurity 4 (CAS 72591-95-8)
- 4-[3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl]-2-(3,4-dimethylphenyl)-1,2-dihydrophthalazin-1-one (CAS 478045-69-1)
- Abemaciclib Impurity 188 (CAS CATO-C4X-2937188)
- Irinotecan Related Compound C DiHCl (CAS CATO-C4X-166768)
- Vonoprazan Fumarate Impurity 5 (CAS 881677-11-8)
- Fluvoxamine impurity 139 (CAS CATO-C4X-195139)
- 1-Piperazinecarbonyl chloride, 4-(methylsulfonyl)- (CAS 65463-96-9)
- Dicyclohexyl(6,7-dihydrodibenzo[e,g][1,4]dioxocin-1-yl)phosphine (CAS 1256169-95-5)
- 2-Hydroxy-5-methyl-N-(1-methyl-1h-pyrazol-3-yl)benzamide (CAS 1133718-02-1)
- 2-Amino-6-(4-nitrophenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile (CAS 338413-84-6)
- Tenofovir disoproxil impurity 123 (CAS 1962114-92-6)
- Sodium 3-chloro-2,4-difluorobenzoate (CAS 1396762-34-7)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
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