Abemaciclib Impurity 188 CAS CATO-C4X-2937188
| CAS No. | CATO-C4X-2937188 |
| Molecular Formula | C21H19ClF2N6 |
| Molecular Weight | 428.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 428.87 g/mol gives Abemaciclib Impurity 188 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Abemaciclib Impurity 188 (CAS CATO-C4X-2937188), a pharmacopoeial impurity reference standard (molecular formula C21H19ClF2N6, MW 428.87 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Abemaciclib Impurity 188 (C21H19ClF2N6) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Abemaciclib Impurity 188 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H19ClF2N6 |
| Molecular Weight | 428.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Abemaciclib Standards
- Abemaciclib Impurity 189 (CAS CATO-C4X-2937189)
- Abemaciclib Impurity 51 (CAS CATO-C4X-293751)
- Abemaciclib Impurity 75 (CAS CATO-C4X-293775)
- Abemaciclib Impurity 9 (CAS CATO-C4X-29379)
- Abemaciclib Impurity 34 (CAS CATO-C4X-293734)
- Abemaciclib Impurity 10 (CAS CATO-C4X-293710)
- Abemaciclib Impurity 41 (CAS CATO-C4X-293741)
- Abemaciclib Impurity 145 (CAS CATO-C4X-2937145)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com