Salbutamol EP Impurity D HCl(R-Isomer) CAS CATO-C4X-1176199
| CAS No. | CATO-C4X-1176199 |
| Molecular Formula | C13H19NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Salbutamol EP Impurity D HCl(R-Isomer) is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Salbutamol EP Impurity D HCl(R-Isomer) (CAS CATO-C4X-1176199) is a certified pharmaceutical impurity reference standard with the molecular formula C13H19NO3HCl and a molecular weight of 273.76 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Salbutamol EP Impurity D HCl(R-Isomer) is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 273.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H19NO3 HCl |
| Molecular Weight | 273.76 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Salbutamol Standards
- Salbutamol Impurity 130 (CAS 115061-55-7)
- Salbutamol Impurity 134 (CAS 115787-50-3)
- Salbutamol Impurity 55 (CAS 115787-52-5)
- Salbutamol Impurity 85 (CAS 115787-52-5（free base）)
- Salbutamol Impurity 87 (CAS 115787-53-6)
- Salbutamol-d3 (CAS 1219798-60-3)
- Salbutamol Impurity 75 (CAS 1221726-71-1)
- Salbutamol Impurity 146 (CAS 124658-76-0)
Recommended Standards
- Clindamycin Impurity 74 (CAS CATO-C4X-134174)
- Lusutrombopag Impurity 13 (CAS CATO-C4X-208413)
- Fluconazole Impurity 24 (CAS CATO-C4X-101924)
- 2-Isopropyl-1,3,4-oxadiazole (CAS 149324-24-3)
- (R)-Propafenone HCl (CAS 107381-35-1)
- 2-(6-oxopiperidin-2-yl)propanedioic acid (CAS 1803612-18-1)
- 5,6-dimethylpyrazin-2-ol (CAS 57229-36-4)
- N-(3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2-methylpropan-2-amine (CAS 2096337-36-7)
- Cephalosporin Impurity 3 (CAS 1269661-24-6)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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