Eltrombopag Impurity 79 CAS CATO-C4X-119879
| CAS No. | CATO-C4X-119879 |
| Molecular Formula | C13H8ClNO5 |
| Molecular Weight | 293.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Eltrombopag Impurity 79.
As a process- or degradation-related impurity, Eltrombopag Impurity 79 (CAS CATO-C4X-119879, C13H8ClNO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Eltrombopag Impurity 79 (C13H8ClNO5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 293.66 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Eltrombopag Impurity 79 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8ClNO5 |
| Molecular Weight | 293.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Eltrombopag Standards
- Eltrombopag Impurity 13 (CAS 376592-58-4)
- Eltrombopag Impurity 100 (CAS 15969-09-2)
- Eltrombopag Impurity 41 (CAS 303730-26-9)
- Eltrombopag Impurity 81 (CAS CATO-C4X-119881)
- Eltrombopag Impurity 87 (CAS CATO-C4X-119887)
- Eltrombopag impurity 139 (CAS CATO-C4X-1198139)
- Eltrombopag Impurity 91 (CAS CATO-C4X-119891)
- Eltrombopag Impurity 56 (CAS 36324-64-8)
Recommended Standards
- Bumetanide Impurity 68 (CAS CATO-C4X-198668)
- 4-Nitrophenyl (5-chloropyridin-2-yl)carbamate (CAS 536746-34-6)
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- 4-Chlorophenyl 5-nitropyridin-2-ylcarbamate (CAS 1984037-71-9)
- Pemafibrate Impurity 18 (CAS CATO-C4X-290318)
- Biotin EP Impurity G Bromide (CAS 33719-11-8)
- Fexofenadine Impurity 28 (CAS CATO-C4X-179428)
- 1-Benzyl-6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine (CAS 23596-27-2)
- 5-(Benzyloxy)-4-hydroxy-3-phenyl-2H-pyrano[2,3-b]quinolin-2-one (CAS 62668-81-9)
- N-(4-Amino-2-methylphenyl)-2-(4-chlorophenoxy)-propanamide (CAS 1020057-45-7)
- 6-Fluoro-N-(pyridin-2-ylmethyl)-1,3-benzothiazol-2-amine (CAS 941867-04-5)
- (E)-3-(4-nitrophenyl)acrylonitrile (CAS 29246-70-6)
- 5-Bromo-3-iodo-2-nitropyridine (CAS 1807213-54-2)
- 149471-11-4 Neuropeptide DF2 L-Phenylalaninamide, L-alpha-aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl- Asp-arg-asn-phe-leu-arg-phe-NH2 Aspartyl-arginyl-asparaginyl-phenylalanyl-leucyl-arginyl-phenylalaninamide L-alpha-Aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl-L-phenylalaninamide DF(2) Neuropeptide Drnflrfamide (CAS 149471-11-4)
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